ArticlePharmacoEconomics2013
Understanding the cost-effectiveness of influenza vaccination in children: methodological choices and seasonal variability.
Article in PharmacoEconomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cost-effectiveness of vaccines for the prevention of seasonal influenza in different age groups: a systematic reviewRevista espanola de salud publica · 2018Pooled it
- Unremarked or Unperformed? Systematic Review on Reporting of Validation Efforts of Health Economic Decision Models in Seasonal Influenza and Early Breast Cancer.PharmacoEconomics · 2016Pooled it
- Estimates of Seasonal Influenza Burden That Could Be Averted by Improved Influenza Vaccines in the Australian Population Aged Under 65 Years, 2015-2019.Influenza and other respiratory viruses · 2024Article
- Application of Dendrimers for the Treatment of Infectious Diseases.Molecules (Basel, Switzerland) · 2018Review
- WHO guide on the economic evaluation of influenza vaccination.Influenza and other respiratory viruses · 2018Review
- Cost-effectiveness of Strategies for Offering Influenza Vaccine in the Pediatric Emergency Department.JAMA pediatrics · 2018Article
- Variation in loss of immunity shapes influenza epidemics and the impact of vaccination.BMC infectious diseases · 2017Article
- Cost-effectiveness analysis of N95 respirators and medical masks to protect healthcare workers in China from respiratory infections.BMC infectious diseases · 2017Article
- Article
- Dealing with Time in Health Economic Evaluation: Methodological Issues and Recommendations for Practice.PharmacoEconomics · 2015Article
- Protection of young children from influenza through universal vaccination.Human vaccines & immunotherapeutics · 2015Review
- Article
- Vaccination of children with a live-attenuated, intranasal influenza vaccine - analysis and evaluation through a Health Technology Assessment.GMS health technology assessment · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe universal vaccination of children for influenza has recently been recommended in the UK and is being considered in other developed countries.
objectivesThe aim of this study was to explore the potential costs and benefits of childhood influenza vaccination to gain a better understanding of the key drivers of cost-effectiveness.
methodsAs our case study we examined the cost-effectiveness of vaccination in Australian schoolchildren using an age-stratified Susceptible Exposed Infectious Recovered model.
resultsThe results of this study highlight the critical role that methodological choices play in determining the cost-effectiveness of influenza vaccination. These choices include decisions about the structure of the model (including/excluding herd immunity) and what costs and benefits to include in the analysis. In scenarios where herd protection was included we estimated that the program was likely to be cost-effective. The study also illustrates the importance of the inherent seasonal variability of influenza, which can produce counter-intuitive results, with low transmission seasons being easier to control by vaccination but resulting in fewer benefits.
conclusionsUniversal childhood influenza vaccination is likely to be cost-effective if a substantial herd protection effect can be achieved by the program. However, it is important that decision makers understand the role of seasonal variability and the impact of alternative methodological choices in economic evaluations of influenza vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.