ArticleCardiovascular toxicology2013
Pulmonary cerium dioxide nanoparticle exposure differentially impairs coronary and mesenteric arteriolar reactivity.
Article in Cardiovascular toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adverse effects and underlying mechanism of rare earth elements.Environmental health : a global access science source · 2025Pooled it
- Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses.Particle and fibre toxicology · 2026Article
- Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling.bioRxiv : the preprint server for biology · 2025Article
- Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Combined cerium and zinc oxide nanoparticles induced hepato-renal damage in rats through oxidative stress mediated inflammation.Scientific reports · 2023Article
- Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats.Particle and fibre toxicology · 2023Article
- Exacerbation of Thrombotic Responses to Silver Nanoparticles in Hypertensive Mouse Model.Oxidative medicine and cellular longevity · 2022Article
- Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy.Particle and fibre toxicology · 2020Article
- Susceptibility Factors in Chronic Lung Inflammatory Responses to Engineered Nanomaterials.International journal of molecular sciences · 2020Review
- Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats.Antioxidants (Basel, Switzerland) · 2020Article
- Inhalation exposure to three-dimensional printer emissions stimulates acute hypertension and microvascular dysfunction.Toxicology and applied pharmacology · 2017Article
- Ultrafine Particulate Matter Increases Cardiac Ischemia/Reperfusion Injury via Mitochondrial Permeability Transition Pore.Cardiovascular toxicology · 2017Article
- Health risk assessment of rare earth elements in cereals from mining area in Shandong, China.Scientific reports · 2017Article
- The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice.International journal of nanomedicine · 2017Article
- Heterogeneous Vascular Bed Responses to Pulmonary Titanium Dioxide Nanoparticle Exposure.Frontiers in cardiovascular medicine · 2017Article
- Metal Nanomaterial Toxicity Variations Within the Vascular System.Current environmental health reports · 2016Review
- Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury.Particle and fibre toxicology · 2016Article
- Direct stimulation of human fibroblasts by nCeO2 in vitro is attenuated with an amorphous silica coating.Particle and fibre toxicology · 2016Article
- Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Cardiac and mitochondrial dysfunction following acute pulmonary exposure to mountaintop removal mining particulate matter.American journal of physiology. Heart and circulatory physiology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protection. These uses of CeO2 NPs present a risk for human exposure; however, to date, no studies have investigated the effects of CeO2 NPs on the microcirculation following pulmonary exposure. Previous studies in our laboratory with other nanomaterials have shown impairments in normal microvascular function after pulmonary exposures. Therefore, we predicted that CeO2 NP exposure would cause microvascular dysfunction that is dependent on the tissue bed and dose. Twenty-four-hour post-exposure to CeO2 NPs (0-400 μg), mesenteric, and coronary arterioles was isolated and microvascular function was assessed. Our results provided evidence that pulmonary CeO2 NP exposure impairs endothelium-dependent and endothelium-independent arteriolar dilation in a dose-dependent manner. The CeO2 NP exposure dose which causes a 50 % impairment in arteriolar function (EC50) was calculated and ranged from 15 to 100 μg depending on the chemical agonist and microvascular bed. Microvascular assessments with acetylcholine revealed a 33-75 % reduction in function following exposure. Additionally, there was a greater sensitivity to CeO2 NP exposure in the mesenteric microvasculature due to the 40 % decrease in the calculated EC50 compared to the coronary microvasculature EC50. CeO2 NP exposure increased mean arterial pressure in some groups. Taken together, these observed microvascular changes may likely have detrimental effects on local blood flow regulation and contribute to cardiovascular dysfunction associated with particle exposure.
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