ArticleCognitive, affective & behavioral neuroscience2013
Amygdala functional connectivity is reduced after the cold pressor task.
Article in Cognitive, affective & behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Temporal dynamics of heart rate variability reveal stressor-specific autonomic patterns: a multi-stressor study.Frontiers in neuroscience · 2026Article
- Neural mechanisms and neuromodulation therapies for non-suicidal self-injury.Molecular psychiatry · 2025Review
- A Novel Investigation of an In-Scanner Alternative to the Cold Pressor Test in Healthy Individuals.Human brain mapping · 2025Article
- Neurosustainability.Frontiers in human neuroscience · 2024Article
- Effects of neuromodulation on cognitive and emotional responses to psychosocial stressors in healthy humans.Neurobiology of stress · 2023Review
- Hormone-based models for comparing menstrual cycle and hormonal contraceptive effects on human resting-state functional connectivity.Frontiers in neuroendocrinology · 2022Article
- Cerebral processing of sharp mechanical pain measured with arterial spin labeling.Brain and behavior · 2022Article
- Amygdala connectivity and implications for social cognition and disorders.Handbook of clinical neurology · 2022Review
- Article
- Acute stress reduces the emotional attentional blink: Evidence from human electrophysiology.Cognitive, affective & behavioral neuroscience · 2021Article
- Brain activity during a post-stress working memory task differs between the hormone-present and hormone-absent phase of hormonal contraception.Neurobiology of stress · 2020Article
- Hormonal contraceptive phases matter: Resting-state functional connectivity of emotion-processing regions under stress.Neurobiology of stress · 2020Article
- Amygdala activity related to perceived social support.Scientific reports · 2020Article
- Imaging Clinically Relevant Pain States Using Arterial Spin Labeling.Pain reports · 2019Article
- Locus Coeruleus Activity Strengthens Prioritized Memories Under Arousal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stress attenuates the flexible updating of aversive value.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Multi-modal neuroimaging of adolescents with non-suicidal self-injury: Amygdala functional connectivity.Journal of affective disorders · 2017Article
- Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses.Human brain mapping · 2016Article
- Acute Stress Dysregulates the LPP ERP Response to Emotional Pictures and Impairs Sustained Attention: Time-Sensitive Effects.Brain sciences · 2015Article
- The influence of acute stress on the regulation of conditioned fear.Neurobiology of stress · 2015Review
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Authors and funding
3 authors.
Funding
Abstract
The amygdala forms a crucial link between central pain and stress systems. Previous research indicates that psychological stress affects amygdala activity, but it is less clear how painful stressors influence subsequent amygdala functional connectivity. In the present study, we used pulsed arterial spin labeling (PASL) to investigate differences in healthy male adults' resting-state amygdala functional connectivity following a cold pressor versus a control task, with the stressor and control conditions being conducted on different days. During the period of peak cortisol response to acute stress (approximately 15-30 min after stressor onset), participants were asked to rest for 6 min with their eyes closed during a PASL scanning sequence. The cold pressor task led to reduced resting-state functional connectivity between the amygdalae and orbitofrontal cortex (OFC) and ventromedial prefrontal cortex, and this occurred irrespective of cortisol release. The stressor also induced greater inverse connectivity between the left amygdala and dorsal anterior cingulate cortex (ACC), a brain region implicated in the down-regulation of amygdala responsivity. Furthermore, the degree of poststressor left amygdala decoupling with the lateral OFC varied according to self-reported pain intensity during the cold pressor task. These findings indicate that the cold pressor task alters amygdala interactions with prefrontal and ACC regions 15-30 min after the stressor, and that these altered functional connectivity patterns are related to pain perception rather than cortisol feedback.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.