ArticleMolecular biology reports2013
Analysis on cDNA sequence, alternative splicing and polymorphisms associated with timing of puberty of Lin28B gene in goats.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.Hormones (Athens, Greece) · 2025Review
- Transcriptome and DNA methylation analysis of the goat pineal gland during puberty.Scientific reports · 2025Article
- Differential Expression of RNAseq Imprinted Genes from Bovine Females Before and After Puberty.Biochemical genetics · 2023Article
- Alternative Splicing Dynamics of the Hypothalamus-Pituitary-Ovary Axis During Pubertal Transition in Gilts.Frontiers in genetics · 2021Article
- Cloning and expression of lin-28 homolog B gene in the onset of puberty in Duolang sheep.Asian-Australasian journal of animal sciences · 2019Article
- Landscape of alternative splicing in Capra_hircus.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, variations in or near Lin28B gene were reported to be associated with timing of human puberty by genome-wide association studies. There have been no reports on that in other mammals. In the present study, a fragment of 5,353 bp of goat Lin28B cDNA, encoding 247 amino acids, was amplified, which contains 744 bp coding region and 4,410 bp 3'-untranslated region (UTR). Two alternative transcripts of Lin28BS (encoding 247 aa) and Lin28BL (encoding 261 aa) were found. Eight mutations in 3'-UTR were detected in nine goat breeds, and the T allele frequencies of A2934T and C3053T in the five sexual precocious breeds were higher than that of the four sexual late-maturing breeds (p<0.05). This may indicate that both the 2934 and 3053 locus may be associated with the age of goat puberty. Our results might expand understanding of the biological pathway of Lin28B gene regulating the timing of mammal puberty.
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Registered trials
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