ArticleSocial psychiatry and psychiatric epidemiology2013
ABC Schizophrenia study: an overview of results since 1996.
Article in Social psychiatry and psychiatric epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Association of Pre-onset Subthreshold Psychotic Symptoms With Longitudinal Outcomes During Treatment of a First Episode of Psychosis.JAMA psychiatry · 2019Trial
- Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026Review
- A transdiagnostic prodrome for severe mental disorders: an electronic health record study.Molecular psychiatry · 2024Article
- Combinations and Temporal Associations Among Precursor Symptoms Before a First Episode of Psychosis.Schizophrenia bulletin · 2024Article
- Article
- The thalamus in psychosis spectrum disorder.Frontiers in neuroscience · 2023Article
- The mood disorder spectrum vs. schizophrenia decision tree: EDIPHAS research into the childhood and adolescence of 205 patients.BMC psychiatry · 2022Article
- Review
- Impact of Comorbid Affective Disorders on Longitudinal Clinical Outcomes in Individuals at Ultra-high Risk for Psychosis.Schizophrenia bulletin · 2022Article
- A computational lens on menopause-associated psychosis.Frontiers in psychiatry · 2022Article
- Hospital Presentation for Self-Harm in Youth as a Risk Marker for Later Psychotic and Bipolar Disorders: A Cohort Study of 59 476 Finns.Schizophrenia bulletin · 2021Article
- Genetic risks of schizophrenia identified in a matched case-control study.European archives of psychiatry and clinical neuroscience · 2021Article
- Timing, Distribution, and Relationship Between Nonpsychotic and Subthreshold Psychotic Symptoms Prior to Emergence of a First Episode of Psychosis.Schizophrenia bulletin · 2021Article
- Self-Schemas and Self-Esteem Discrepancies in Subclinical Paranoia: The Essential Role of Depressive Symptoms.Frontiers in psychiatry · 2021Article
- Neuropsychological profile of children and adolescents with psychosis risk syndrome: the CAPRIS study.European child & adolescent psychiatry · 2020Article
- The Global Functioning: Social and Role Scales-Further Validation in a Large Sample of Adolescents and Young Adults at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2019Article
- Clinical Correlates of Insulin Resistance in Chronic Schizophrenia: Relationship to Negative Symptoms.Frontiers in psychiatry · 2019Article
- From Onset and Prodromal Stage to a Life-Long Course of Schizophrenia and Its Symptom Dimensions: How Sex, Age, and Other Risk Factors Influence Incidence and Course of Illness.Psychiatry journal · 2019Article
- The Relationship Between Course of Illness and β-Endorphin Plasma Levels in Patients with Schizophrenia.Neuropsychiatric disease and treatment · 2019Article
- Latent Profile Analysis and Conversion to Psychosis: Characterizing Subgroups to Enhance Risk Prediction.Schizophrenia bulletin · 2018Article
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Authors and funding
3 authors.
Funding
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Abstract
purposeThe ABC Schizophrenia study, led by a single research team, investigated a schizophrenia sample systematically over quarter of a century. This paper summarises results from 1996 onwards. The initial goals were to explain the considerably higher age at first admission in women, and to obtain precise information on the onset and early course of schizophrenia as a prerequisite for early intervention.
methodThe study was hypothesis-driven. People with schizophrenia were compared in the prodrome and at first admission to those with unipolar depression and to healthy controls. We analysed the medium-term (5-year) and the long-term (12-year) course of schizophrenia, its symptom dimensions, social parameters and predictors. SAMPLES: (1) 276 population-based first admissions (232 first episodes) of schizophrenia (age range 12-59 years); (2) a subsample of 130 first admissions for schizophrenia; (3) 130 first admissions for unipolar depression; (4) 130 healthy population controls and (5) 1,109 consecutive first admissions for schizophrenia spectrum disorder without an age limit.
resultsThe prodromal stages of schizophrenia and depression were very similar until positive symptoms appeared. The most frequent symptom in schizophrenia was depressed mood. The course of psychosis from prodrome to 12 years following first admission was very variable. From 5 to 12 years after first admission the course was characterised by irregular exacerbations of the main symptom dimensions, with no overall deterioration or improvement.
conclusionsSchizophrenic psychosis and severe affective disorder, rather than representing discrete illnesses, probably mark different stages in the manifestation of psychopathology produced by various degrees of brain dysfunction.
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