Evidence map›Paper›PMID 23644722›Full record

ArticleSocial psychiatry and psychiatric epidemiology2013

Social support and physical activity as moderators of life stress in predicting baseline depression and change in depression over time in the Women's Health Initiative.

Lisa A Uebelacker, Charles B Eaton, Risa Weisberg, Megan Sands, Carla Williams, Darren Calhoun, Joann E Manson, Natalie L Denburg, Teletia Taylor

Open access · greenAbstract read
In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
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  18. Relation between anxiety, depression, and physical activity and performance in maintenance hemodialysis patients.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Lisa A UebelackerAlpert Medical School of Brown University, Center for Primary Care and Prevention, Memorial Hospital of Rhode Island and Brown University, 111 Brewster Street, Pawtucket, RI, 02860, USA, luebelacker@butler.org.
Charles B Eaton
Risa Weisberg
Megan Sands
Carla Williams
Darren Calhoun
Joann E Manson
Natalie L Denburg
Teletia Taylor
Brown University · USHoward University · USHarvard University · USPhoenix (United States) · USUniversity of Iowa · USUniversity of Pennsylvania · US

Funding

VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032111 · WH · EMORY UNIVERSITY · PI WATTS, NELSON · 1993 to 2001
$1.6M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032105 · WH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 1993 to 2000
$1.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032119 · WH · MEMORIAL HOSPITAL OF RHODE ISLAND · PI ASSAF, ANNLOUISE R. · 1993 to 2000
$1.2M
VANGUARD CENTER FOR WOMENS HEALTH INITIATIVEN01WH032100 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERESFORD, SHIRLEY AA · 1993 to 2001
$1.1M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032118 · WH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, KAREN C · 1993 to 2000
$992k
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032122 · WH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TREVISAN, MAURIZIO · 1993 to 2000
$927k
VANGUARD CENTER FOR WOMENS HEALTH INITIATIVEN01WH032108 · WH · NORTHWESTERN UNIVERSITY · PI GREENLAND, PHILIP · 1993 to 2000
$919k
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032115 · WH · UNIVERSITY OF ARIZONA · PI BASSFORD, TAMSEN E · 1993 to 2000
$196k
WHI NIH HHS N01 WH022110WHI NIH HHS N01 WH024152WHI NIH HHS N01 WH032100WHI NIH HHS N01 WH032105WHI NIH HHS N01 WH032108WHI NIH HHS N01 WH032111WHI NIH HHS N01 WH032115WHI NIH HHS N01 WH032118WHI NIH HHS N01 WH032119WHI NIH HHS N01 WH032122
6 · The paper itself

Abstract

purposeTo determine whether social support and/or physical activity buffer the association between stressors and increasing risk of depression symptoms at baseline and at 3-year follow-up.

methodsThis is a secondary analysis of data from the Women's Health Initiative Observational Study. 91,912 community-dwelling post-menopausal women participated in this prospective cohort study. Depression symptoms were measured at baseline and 3 years later; social support, physical activity, and stressors were measured at baseline.

resultsStressors at baseline, including verbal abuse, physical abuse, caregiving, social strain, negative life events, financial stress, low income, acute pain, and a greater number of chronic medical conditions, were all associated with higher levels of depression symptoms at baseline and new onset elevated symptoms at 3-year follow-up. Social support and physical activity were associated with lower levels of depressive symptoms. Contrary to expectation, more social support at baseline strengthened the association between concurrent depression and physical abuse, social strain, caregiving, and low income. Similarly, more social support at baseline increased the association between financial stress, income, and pain on new onset depression 3 years later. Physical activity similarly moderated the effect of caregiving, income, and pain on depression symptoms at baseline.

conclusionStressors, social support, and physical activity showed predicted main effect associations with depression. Multiplicative interactions were small in magnitude and in the opposite direction of what was expected.

Indexed as

Motor ActivitySocial SupportAgedDepressionExerciseFemaleFollow-Up StudiesHealth StatusHumansMiddle AgedPostmenopauseProspective StudiesRegression AnalysisRisk FactorsSocioeconomic FactorsStress, Psychological

Identifiers

PMID23644722
PMCPMC3796164
OpenAlexW2093524776

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.