ArticleEuropean biophysics journal : EBJ2013
Different modes of growth cone collapse in NG 108-15 cells.
Article in European biophysics journal : EBJ, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Radial Glial Cells: New Views on Old Questions.Neurochemical research · 2021Article
- ConFiG: Contextual Fibre Growth to generate realistic axonal packing for diffusion MRI simulation.NeuroImage · 2020Article
- Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A.Frontiers in cellular neuroscience · 2015Article
- Loop formation and self-fasciculation of cortical axon using photonic guidance at long working distance.Scientific reports · 2014Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
In the fundamental process of neuronal path-finding, a growth cone at the tip of every neurite detects and follows multiple guidance cues regulating outgrowth and initiating directional changes. While the main focus of research lies on the cytoskeletal dynamics underlying growth cone advancement, we investigated collapse and retraction mechanisms in NG108-15 growth cones transiently transfected with mCherry-LifeAct and pCS2+/EMTB-3XGFP for filamentous actin and microtubules, respectively. Using fluorescence time lapse microscopy we could identify two distinct modes of growth cone collapse leading either to neurite retraction or to a controlled halt of neurite extension. In the latter case, lateral movement and folding of actin bundles (filopodia) confine microtubule extension and limit microtubule-based expansion processes without the necessity of a constantly engaged actin turnover machinery. We term this previously unreported second type fold collapse and suggest that it marks an intermediate-term mode of growth regulation closing the gap between full retraction and small scale fluctuations.
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