ArticleBrain structure & function2014
Effects of stress on AMPA receptor distribution and function in the basolateral amygdala.
Article in Brain structure & function, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Specific behaviors during auditory fear conditioning and postsynaptic expression of AMPA receptors in the basolateral amygdala predict interindividual differences in fear generalization in male rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Neurobiology of Depression: Chronic Stress Alters the Glutamatergic System in the Brain-Focusing on AMPA Receptor.Biomedicines · 2022Review
- Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes.Translational psychiatry · 2019Article
- Traumatic Stress Produces Delayed Alterations of Synaptic Plasticity in Basolateral Amygdala.Frontiers in psychology · 2019Article
- Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- NPY Induces Stress Resilience via Downregulation ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Repeated shock stress facilitates basolateral amygdala synaptic plasticity through decreased cAMP-specific phosphodiesterase type IV (PDE4) expression.Brain structure & function · 2018Article
- miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala.Molecular neurobiology · 2018Article
- Putative Inflammatory Sensitive Mechanisms Underlying Risk or Resilience to Social Stress.Frontiers in behavioral neuroscience · 2018Review
- The potential role of exercise in chronic stress-related changes in AMPA receptor phenotype underlying synaptic plasticity.Journal of exercise nutrition & biochemistry · 2017Article
- Sucrose-induced plasticity in the basolateral amygdala in a 'comfort' feeding paradigm.Brain structure & function · 2017Article
- Disruption of GluA2 phosphorylation potentiates stress responsivity.Behavioural brain research · 2017Article
- Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits.Molecular brain · 2017Article
- Amygdala volume is reduced in early course schizophrenia.Psychiatry research. Neuroimaging · 2016Article
- Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Molecular Mechanisms of Stress-Induced Increases in Fear Memory Consolidation within the Amygdala.Frontiers in behavioral neuroscience · 2016Article
- Structural and functional characterization of dendritic arbors and GABAergic synaptic inputs on interneurons and principal cells in the rat basolateral amygdala.Journal of neurophysiology · 2015Article
- Qualitatively different effect of repeated stress during adolescence on principal neuron morphology across lateral and basal nuclei of the rat amygdala.Neuroscience · 2015Article
- Stress and tinnitus.HNO · 2015Article
- Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Stress is a growing public health concern and can lead to significant disabilities. The neural response to stressors is thought to be dependent on the extended amygdala. The basolateral amygdala (BLA) is responsible for associations of sensory stimuli with emotional valence and is thought to be involved in stress-induced responses. Previous behavioral and electrophysiological experiments demonstrate that, in response to stress, changes occur in glutamatergic neurotransmission within the BLA and, in particular in transmission at AMPA receptors. Given the established role of AMPA receptors in memory and synaptic plasticity, we tested the hypothesis that stress produces alterations in the distribution of these receptors in a way that might account for stress-induced alterations in amygdala circuitry function. We examined the subcellular localization of GluR1 subunits of the AMPA receptor and the electrophysiological characteristics of BLA principal neurons in an animal model of unpredictable stress. Compared to controls, we demonstrated an increase in the ratio of labeled spines to labeled dendritic shafts in the BLA of rats 6 and 14 days post-stress, but not 1 day post-stress. Furthermore, the frequency of mini-EPSCs was increased in stressed animals without a change in general membrane properties, mini-EPSC amplitude, or in paired pulse modulation of glutamate release. Taken together, these data suggest that the shift of GluR1-containing AMPA receptors from dendritic stores into spines may be in part responsible for the persistent behavioral alterations observed following severe stressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.