ArticleNature nanotechnology2013
In vivo magnetic resonance imaging of hyperpolarized silicon particles.
Article in Nature nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Deuterated Nanopolymers for Renal and Lymphatic Imaging via Quantitative Deuterium MRI.Nano letters · 2025Article
- Controlled synthesis and characterization of porous silicon nanoparticles for dynamic nuclear polarization.Nanoscale · 2024Article
- Coherent spin dynamics between electron and nucleus within a single atom.Nature communications · 2024Article
- Design and synthesis of a novel chiral photoacoustic probe and accurate imaging detection of hydrogen peroxide in vivo.Analytical and bioanalytical chemistry · 2024Article
- Large Room Temperature Bulk DNP ofThe journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics.ChemMedChem · 2022Review
- Optical Dynamic Nuclear Polarization ofMolecules (Basel, Switzerland) · 2022Article
- Electroplated waveguides to enhance DNP and EPR spectra of silicon and diamond particles.Magnetic resonance (Gottingen, Germany) · 2022Article
- Hyperpolarized MRI with silicon micro and nanoparticles: Principles and applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Dynamic Nuclear Polarization of Silicon Carbide Micro- and Nanoparticles.ACS applied materials & interfaces · 2021Article
- Background-free dual-mode optical andProceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Multifield and inverse-contrast switching of magnetocaloric high contrast ratio MRI labels.Magnetic resonance in medicine · 2021Article
- Beyond Colonoscopy: Exploring New Cell Surface Biomarkers for Detection of Early, Heterogenous Colorectal Lesions.Frontiers in oncology · 2021Review
- Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy.Pharmaceutics · 2020Review
- Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance.Cardiovascular drugs and therapy · 2020Review
- Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei.Magma (New York, N.Y.) · 2020Review
- Improving nanotherapy delivery and action through image-guided systems pharmacology.Theranostics · 2020Review
- Phase-Encoded Hyperpolarized Nanodiamond for Magnetic Resonance Imaging.Scientific reports · 2019Article
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5 authors.
Funding
Abstract
Silicon-based micro- and nanoparticles have gained popularity in a wide range of biomedical applications due to their biocompatibility and biodegradability in vivo, as well as their flexible surface chemistry, which allows drug loading, functionalization and targeting. Here, we report direct in vivo imaging of hyperpolarized (29)Si nuclei in silicon particles by magnetic resonance imaging. Natural physical properties of silicon provide surface electronic states for dynamic nuclear polarization, extremely long depolarization times, insensitivity to the in vivo environment or particle tumbling, and surfaces favourable for functionalization. Potential applications to gastrointestinal, intravascular and tumour perfusion imaging at subpicomolar concentrations are presented. These results demonstrate a new background-free imaging modality applicable to a range of inexpensive, readily available and biocompatible silicon particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.