ArticleNature materials2013
A transparent organic transistor structure for bidirectional stimulation and recording of primary neurons.
Article in Nature materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Bioelectric calcium transport and activation in mammalian cells using field-focused DNA-carbon nanotube meshes.Science advances · 2026Article
- Physical echo state network based on the nonlinearity and dynamic response of ambipolar heterostructure transistors.Nature communications · 2026Article
- Neural vs Neuromorphic Interfaces: Where Are We Standing?Chemical reviews · 2025Review
- Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes.Nature nanotechnology · 2024Article
- A stretchable, electroconductive tissue adhesive for the treatment of neural injury.Bioengineering & translational medicine · 2024Article
- A silicon diode-based optoelectronic interface for bidirectional neural modulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces.APL bioengineering · 2023Article
- Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.Nature biomedical engineering · 2023Article
- Activating Endogenous Neurogenesis for Spinal Cord Injury Repair: Recent Advances and Future Prospects.Neurospine · 2023Article
- Organic electrochemical neurons and synapses with ion mediated spiking.Nature communications · 2022Article
- Ion-Selective Membrane-Coated Graphene-Hexagonal Boron Nitride Heterostructures for Field-Effect Ion Sensing.ACS omega · 2021Article
- An organic transistor matrix for multipoint intracellular action potential recording.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats.Neural regeneration research · 2021Article
- High Aspect Ratio and Light-Sensitive Micropillars Based on a Semiconducting Polymer Optically Regulate Neuronal Growth.ACS applied materials & interfaces · 2021Article
- Polyaniline nano-needles into electrospun bio active fibres supportRSC advances · 2021Article
- Recent Advances in Electrical Neural Interface Engineering: Minimal Invasiveness, Longevity, and Scalability.Neuron · 2020Review
- Novel electrode technologies for neural recordings.Nature reviews. Neuroscience · 2019Review
- Organic Bioelectronics: Materials and Biocompatibility.International journal of molecular sciences · 2018Review
- Mesh electronics: a new paradigm for tissue-like brain probes.Current opinion in neurobiology · 2018Review
- Neural Recording and Modulation Technologies.Nature reviews. Materials · 2017Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Real-time stimulation and recording of neural cell bioelectrical activity could provide an unprecedented insight in understanding the functions of the nervous system, and it is crucial for developing advanced in vitro drug screening approaches. Among organic materials, suitable candidates for cell interfacing can be found that combine long-term biocompatibility and mechanical flexibility. Here, we report on transparent organic cell stimulating and sensing transistors (O-CSTs), which provide bidirectional stimulation and recording of primary neurons. We demonstrate that the device enables depolarization and hyperpolarization of the primary neuron membrane potential. The transparency of the device also allows the optical imaging of the modulation of the neuron bioelectrical activity. The maximal amplitude-to-noise ratio of the extracellular recording achieved by the O-CST device exceeds that of a microelectrode array system on the same neuronal preparation by a factor of 16. Our organic cell stimulating and sensing device paves the way to a new generation of devices for stimulation, manipulation and recording of cell bioelectrical activity in vitro and in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.