ReviewJournal of molecular medicine (Berlin, Germany)2013
Insights into mitochondrial quality control pathways and Parkinson's disease.
Review in Journal of molecular medicine (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model.Resuscitation plus · 2021Article
- Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement.International journal of molecular sciences · 2019Article
- Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway.Redox biology · 2018Review
- Fusion or Fission: The Destiny of Mitochondria In Traumatic Brain Injury of Different Severities.Scientific reports · 2017Article
- Enhancing NADBiology open · 2017Article
- Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease.Cell death & disease · 2016Article
- Rethinking energy in parkinsonian motor symptoms: a potential role for neural metabolic deficits.Frontiers in systems neuroscience · 2014Article
- Understanding neuronal dysfunction and loss in neurodegenerative disease.Journal of molecular medicine (Berlin, Germany) · 2013Article
- NMR Metabolomics Analysis of Parkinson's Disease.Current MetabolomicsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The brain uses more energy than any other human organ, accounting for 20 % of the body's total demand. Mitochondria are energy-converting organelles with a pivotal role in meeting the energetic needs of the human brain. Therefore, the decline of these cellular powerhouses can have a negative impact on the function and plasticity of neurons and is believed to have a prominent role in ageing and in the occurrence of several neurological disorders, such as Parkinson's disease (PD). As a consequence of their physiological roles, mitochondria are subjected to high levels of stress and have therefore developed several stress-protective mitochondrial quality control mechanisms that ensure the optimal activity of their molecular machinery. Here, we review some of the most recent advances in our understanding of the regulation of mitochondrial stress pathways with particular emphasis on how defective mitochondrial quality control might contribute to PD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.