ArticleBehavioural brain research2013
Influence of chronic moderate sleep restriction and exercise training on anxiety, spatial memory, and associated neurobiological measures in mice.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Does Sleep Moderate the Effects of Exercise Training or Complex Mental and Social Activities on Cognitive Function in Adults With Chronic Stroke? Secondary Analysis of a Randomized Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- The gut microbiota-metabolite-target axis in insomnia: network pharmacology and gut microbiota profiling insights into pathogenesis and intervention with Cinnamomi Cortex-Gardeniae Fructus.Frontiers in microbiology · 2026Article
- Interplay Between Vestibular Dysfunction and Sleep Disorders.Current medical science · 2025Review
- Harnessing Passive Pulsatile Shear Stress for Alzheimer's Disease Prevention and Intervention.Journal of Alzheimer's disease : JAD · 2024Review
- Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review.Dementia & neuropsychologia · 2024Review
- Chronic Vestibular Hypofunction Is Associated with Impaired Sleep: Results from the DizzyReg Patient Registry.Journal of clinical medicine · 2023Article
- Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary.GeroScience · 2023Review
- Lifestyle Adjustment: Influential Risk Factors in Cognitive Aging.Advances in experimental medicine and biology · 2023Article
- Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation.Translational psychiatry · 2021Article
- Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression.Neurochemical research · 2020Review
- MLC901 during sleep deprivation rescues fear memory disruption in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Differential effects of physical activity and sleep duration on cognitive function in young adults.Journal of sport and health science · 2018Article
- Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia.Neurobiology of learning and memory · 2016Article
- Acute sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression.Neuroscience letters · 2014Article
- Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
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Authors and funding
4 authors.
Funding
Abstract
Sleep deprivation can have deleterious effects on cognitive function and mental health. Moderate exercise training has myriad beneficial effects on cognition and mental health. However, physiological and behavioral effects of chronic moderate sleep restriction and its interaction with common activities, such as moderate exercise training, have received little investigation. The aims of this study were to examine the effects of chronic moderate sleep restriction and moderate exercise training on anxiety-related behavior, spatial memory, and neurobiological correlates in mice. Male mice were randomized to one of four 11-week treatments in a 2 [sleep restriction (∼4h loss/day) vs. ad libitum sleep] × 2 [exercise (1h/day/6 d/wk) vs. sedentary activity] experimental design. Anxiety-related behavior was assessed with the elevated-plus maze, and spatial learning and memory were assessed with the Morris water maze. Chronic moderate sleep restriction did not alter anxiety-related behavior, but exercise training significantly attenuated anxiety-related behavior. Spatial learning and recall, hippocampal cell activity (i.e., number of c-Fos positive cells), and brain derived neurotrophic factor were significantly lower after chronic moderate sleep restriction, but higher after exercise training. Further, the benefit of exercise training for some memory variables was evident under normal sleep, but not chronic moderate sleep restriction conditions. These data indicate clear detrimental effects of chronic moderate sleep restriction on spatial memory and that the benefits of exercise training were impaired after chronic moderate sleep restriction.
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