ArticleBehavioural brain research2013
Optogenetic investigation of the role of the superior colliculus in orienting movements.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata.Neuroscience · 2026Article
- Eye-head coordination during goal-directed orienting in mice.Communications biology · 2026Article
- Eye-head coordination during goal-directed orienting in mice.bioRxiv : the preprint server for biology · 2026Article
- Stimulus-dependent differences in cortical versus subcortical contributions to visual detection in mice.Current biology : CB · 2024Article
- Pathways from the Superior Colliculus to the Basal Ganglia.Current neuropharmacology · 2024Review
- Superior colliculus bidirectionally modulates choice activity in frontal cortex.Nature communications · 2023Article
- Neural Circuit Mechanisms Involved in Animals' Detection of and Response to Visual Threats.Neuroscience bulletin · 2023Review
- Superior colliculus cell types bidirectionally modulate choice activity in frontal cortex.bioRxiv : the preprint server for biology · 2023Article
- Cortical-subcortical interactions in goal-directed behavior.Physiological reviews · 2023Review
- Functional Organisation of the Mouse Superior Colliculus.Frontiers in neural circuits · 2022Review
- Functional coupling between target selection and acquisition in the superior colliculus.Journal of neurophysiology · 2021Article
- Disrupted basal ganglia output during movement preparation in hemiparkinsonian mice is consistent with behavioral deficits.Journal of neurophysiology · 2021Article
- Organization of the inputs and outputs of the mouse superior colliculus.Nature communications · 2021Article
- Inhibitory neurons in the superior colliculus mediate selection of spatially-directed movements.Communications biology · 2021Article
- Article
- Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior.Nature communications · 2020Article
- Monosynaptic inputs to specific cell types of the intermediate and deep layers of the superior colliculus.The Journal of comparative neurology · 2020Article
- Spatial representations in the superior colliculus are modulated by competition among targets.Neuroscience · 2019Article
- Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
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3 authors.
Funding
Abstract
In vivo studies have demonstrated that the superior colliculus (SC) integrates sensory information and plays a role in controlling orienting motor output. However, how the complex microcircuitry within the SC, as documented by slice studies, subserves these functions is unclear. Optogenetics affords the potential to examine, in behaving animals, the functional roles of specific neuron types that comprise heterogeneous nuclei. As a first step toward understanding how SC microcircuitry underlies motor output, we applied optogenetics to mice performing an odor discrimination task in which sensory decisions are reported by either a leftward or rightward SC-dependent orienting movement. We unilaterally expressed either channelrhodopsin-2 or halorhodopsin in the SC and delivered light in order to excite or inhibit motor-related SC activity as the movement was planned. We found that manipulating SC activity predictably affected the direction of the selected movement in a manner that depended on the difficulty of the odor discrimination. This study demonstrates that the SC plays a similar role in directional orienting movements in mice as it does in other species, and provides a framework for future investigations into how specific SC cell types contribute to motor control.
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