ArticleActa biomaterialia2013
Microstructural characterization of vocal folds toward a strain-energy model of collagen remodeling.
Article in Acta biomaterialia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A fibril-scale visco-hyperelastic model for the mechanics of vocal-fold tissues.Frontiers in bioengineering and biotechnology · 2025Article
- Flow-induced oscillations of vocal-fold replicas with tuned extensibility and material properties.Scientific reports · 2023Article
- An Euler-Bernoulli-type beam model of the vocal folds for describing curved and incomplete glottal closure patterns.Journal of the mechanical behavior of biomedical materials · 2023Article
- Vocal fold restoration after scarring: biocompatibility and efficacy of an MSC-based bioequivalent.Stem cell research & therapy · 2023Article
- Article
- Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches.Stem cell research & therapy · 2022Review
- Mechanics of gelatin-based hydrogels during finite strain tension, compression and shear.Frontiers in bioengineering and biotechnology · 2022Article
- Label-free and noninvasive method for assessing the metabolic status in type 2 diabetic rats with myocardium diastolic dysfunction.Biomedical optics express · 2021Article
- Culture of Mesenchymal Stem Cells in a Hydrogel Model of Vocal Fold Lamina Propria.Regenerative engineering and translational medicine · 2019Article
- Structural constitutive modeling of the anisotropic mechanical properties of human vocal fold lamina propria.The Journal of the Acoustical Society of America · 2019Article
- Multimodal virtual histology of rabbit vocal folds by nonlinear microscopy and nano computed tomography.Biomedical optics express · 2019Article
- 3D multiscale imaging of human vocal folds using synchrotron X-ray microtomography in phase retrieval mode.Scientific reports · 2018Article
- Mechanics of human voice production and control.The Journal of the Acoustical Society of America · 2016Article
- Cogels of Hyaluronic Acid and Acellular Matrix for Cultivation of Adipose-Derived Stem Cells: Potential Application for Vocal Fold Tissue Engineering.BioMed research international · 2016Article
- Microstructural and mechanical characterization of scarred vocal folds.Journal of biomechanics · 2015Article
- Study of extracellular matrix in vocal fold biomechanics using a two-phase model.Biomechanics and modeling in mechanobiology · 2015Article
- Determination of the elastic properties of rabbit vocal fold tissue using uniaxial tensile testing and a tailored finite element model.Journal of the mechanical behavior of biomedical materials · 2014Article
- An in vivo study of composite microgels based on hyaluronic acid and gelatin for the reconstruction of surgically injured rat vocal folds.Journal of speech, language, and hearing research : JSLHR · 2014Article
- Nanoscale viscoelasticity of extracellular matrix proteins in soft tissues: A multiscale approach.Journal of the mechanical behavior of biomedical materials · 2014Article
- Indentation of poroviscoelastic vocal fold tissue using an atomic force microscope.Journal of the mechanical behavior of biomedical materials · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Collagen fibrils are believed to control the immediate deformation of soft tissues under mechanical load. Most extracellular matrix proteins remain intact during frozen sectioning, which allows them to be scanned using atomic force microscopy (AFM). Collagen fibrils are distinguishable because of their periodic roughness wavelength. In the present study, the shape and organization of collagen fibrils in dissected porcine vocal folds were quantified using nonlinear laser scanning microscopy data at the micrometer scale and AFM data at the nanometer scale. Rope-shaped collagen fibrils were observed. The geometric characteristics for the fibrils were fed into a hyperelastic model to predict the biomechanical response of the tissue. The model simulates the micrometer-scale unlocking behavior of collagen bundles when extended from their unloaded configuration. Force spectroscopy using AFM was used to estimate the stiffness of collagen fibrils (1±0.5MPa). The presence of rope-shaped fibrils is postulated to change the slope of the force-deflection response near the onset of nonlinearity. The proposed model could ultimately be used to evaluate changes in elasticity of soft tissues that result from the collagen remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.