ReviewOral surgery, oral medicine, oral pathology and oral radiology2013
Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy.
Review in Oral surgery, oral medicine, oral pathology and oral radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the effects of acupuncture on xerostomia and hyposalivation.BMC complementary and alternative medicine · 2018Pooled it
- Evaluating ChatGPT's Effectiveness for Arabic Dry Mouth Patient Education.Healthcare (Basel, Switzerland) · 2026Article
- Fostering cell-cell interactions and integrating angiocrine factors to promote the development of salivary microtissues in 3D.Bioengineering & translational medicine · 2026Article
- Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023Review
- Basement Membrane Mimetic Hydrogel Cooperates with Rho-Associated Protein Kinase Inhibitor to Promote the Development of Acini-Like Salivary Gland Spheroids.Advanced nanobiomed research · 2023Article
- AMPK Activation Restores Salivary Function Following Radiation Treatment.Journal of dental research · 2023Article
- Quality of Life and Aesthetic Satisfaction in Patients Who Underwent the "Commando Operation" with Pectoralis Major Myocutaneus Flap Reconstruction-A Case Series Study.Healthcare (Basel, Switzerland) · 2022Article
- Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.PNAS nexus · 2022Article
- A Computational Text Mining-Guided Meta-Analysis Approach to Identify Potential Xerostomia Drug Targets.Journal of clinical medicine · 2022Article
- The relationship between the severity of oral dryness and the use of dry-mouth interventions by various subgroups of dry-mouth patients.Clinical oral investigations · 2022Article
- Evaluation of the salivary function of patients in treatment with radiotherapy for head and neck cancer submitted to photobiomodulation.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Building a Functional Salivary Gland for Cell-Based Therapy: More than Secretory Epithelial Acini.Tissue engineering. Part A · 2020Review
- Where Dysphagia Begins: Polypharmacy and Xerostomia.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2020Article
- Impact of xerostomia on the quality of life of patients submitted to head and neck radiotherapy.Medicina oral, patologia oral y cirugia bucal · 2019Article
- Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia.International journal of molecular sciences · 2019Review
- RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.Development (Cambridge, England) · 2018Article
- Biopolymeric Mucin and Synthetic Polymer Analogs: Their Structure, Function and Role in Biomedical Applications.Polymers · 2016Review
- Adipose Mesenchymal Stem Cell Secretome Modulated in Hypoxia for Remodeling of Radiation-Induced Salivary Gland Damage.PloS one · 2015Article
- Oral evaluation and procedures performed by dentists in patients admitted to the intensive care unit of a cancer center.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Article
- Evaluation and management of dry mouth and its complications in rheumatology practice.Expert review of clinical immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Head and neck (H&N) radiation therapy (RT) can induce irreversible damage to the salivary glands thereby causing long-term xerostomia or dry mouth in 68%-85% of the patients. Not only does xerostomia significantly impair patients' quality-of-life (QOL) but it also has important medical sequelae, incurring high medical and dental costs. In this article, we review various measures to assess xerostomia and evaluate current and emerging solutions to address this condition in H&N cancer patients. These solutions typically seek to accomplish 1 of the 4 objectives: (1) to protect the salivary glands during RT, (2) to stimulate the remaining gland function, (3) to treat the symptoms of xerostomia, or (4) to regenerate the salivary glands. For each treatment, we assess its mechanisms of action, efficacy, safety, clinical utilization, and cost. We conclude that intensity-modulated radiation therapy is both the most widely used prevention approach and the most cost-effective existing solution and we highlight novel and promising techniques on the cost-effectiveness landscape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.