ArticleAmerican journal of human genetics2013
Incidental variants are critical for genomics.
Article in American journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Towards a Responsible Transition to Learning Healthcare Systems in Precision Medicine: Ethical Points to Consider.Journal of personalized medicine · 2021Review
- Article
- Improving recommendations for genomic medicine: building an evolutionary process from clinical practice advisory documents to guidelines.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Review
- Genomic sequencing identifies secondary findings in a cohort of parent study participants.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Incidental and clinically actionable genetic variants in 1005 whole exomes and genomes from Qatar.Molecular genetics and genomics : MGG · 2018Article
- Navigating the research-clinical interface in genomic medicine: analysis from the CSER Consortium.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Informed Consent in Translational Genomics: Insufficient Without Trustworthy Governance.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2018Article
- CAGI4 SickKids clinical genomes challenge: A pipeline for identifying pathogenic variants.Human mutation · 2017Article
- Lost in translation: returning germline genetic results in genome-scale cancer research.Genome medicine · 2017Article
- Recommendations for the integration of genomics into clinical practice.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Review
- Towards a European consensus for reporting incidental findings during clinical NGS testing.European journal of human genetics : EJHG · 2015Article
- Research participants in NGS studies want to know about incidental findings.European journal of human genetics : EJHG · 2015Article
- Societal preferences for the return of incidental findings from clinical genomic sequencing: a discrete-choice experiment.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2015Article
- Patients' views on incidental findings from clinical exome sequencing.Applied & translational genomics · 2015Article
- The translational potential of research on the ethical, legal, and social implications of genomics.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Review
- Utility of next generation sequencing in clinical primary immunodeficiencies.Current allergy and asthma reports · 2014Article
- Attitudes of genetics professionals toward the return of incidental results from exome and whole-genome sequencing.American journal of human genetics · 2014Article
- Article
- Hypothesis-generating research and predictive medicine.Genome research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The topic of incidental variants detected through exome and genome sequencing is controversial, both in clinical practice and in research. The arguments for and against the deliberate analysis and return of incidental variants focus on issues of clinical validity, clinical utility, autonomy, clinical and research infrastructure and costs, and, in the research arena, therapeutic misconception. These topics are briefly reviewed and an argument is made that these variants are the future of genomic medicine. As a field, we should take full advantage of all opportunities to study these variants by searching them out, returning them to patients and research participants, and studying their utility for predictive medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.