ArticleAtherosclerosis2013
The effect of HIV infection on atherosclerosis and lipoprotein metabolism: a one year prospective study.
Article in Atherosclerosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- HIV disease, metabolic dysfunction and atherosclerosis: A three year prospective study.PloS one · 2019Trial
- Plasma cholesterol efflux capacity from human THP-1 macrophages is reduced in HIV-infected patients: impact of HAART.Journal of lipid research · 2015Trial
- HDL dysfunction: a role in the pathogenesis of cardiometabolic syndrome in chronic HIV infection?Metabolism: clinical and experimental · 2026Review
- Article
- New insights into the emerging effects of inflammatory response on HDL particles structure and function.Molecular biology reports · 2021Review
- Comparison of Predicted Cardiovascular Risk Profiles by Different CVD Risk-Scoring Algorithms between HIV-1-Infected and Uninfected Adults: A Cross-Sectional Study in Tanzania.HIV/AIDS (Auckland, N.Z.) · 2021Article
- Aortic stiffness and central hemodynamics in treatment-naïve HIV infection: a cross-sectional study.BMC cardiovascular disorders · 2020Article
- Coronary Microvascular Dysfunction in HIV: A Review.Journal of the American Heart Association · 2020Review
- Subclinical atherosclerosis and associated risk factors among HIV-infected adults in Jos, North Central Nigeria: a cross-sectional study.The Pan African medical journal · 2020Article
- Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men.International journal of medical sciences · 2019Article
- The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis.Experimental and therapeutic medicine · 2018Article
- Atherosclerosis in subjects newly diagnosed with human immunodeficiency virus infection.Bioscience reports · 2018Observational
- UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters.Scientific reports · 2017Article
- Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV.Current hypertension reports · 2016Review
- Lipid metabolism in patients infected with Nef-deficient HIV-1 strain.Atherosclerosis · 2016Article
- HIV infection induces structural and functional changes in high density lipoproteins.Atherosclerosis · 2015Article
- Brachial and central blood pressure in HIV-infected subjects.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Metabolomics specificity of tuberculosis plasma revealed by (1)H NMR spectroscopy.Tuberculosis (Edinburgh, Scotland) · 2015Article
- Interaction of pathogens with host cholesterol metabolism.Current opinion in lipidology · 2014Review
- Cardiovascular disease risk in an aging HIV population: not just a question of biology.Current opinion in HIV and AIDS · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesHIV infection is associated with dyslipidaemia and increased risk of cardiovascular disease. The effects of HIV infection and antiretroviral treatment on surrogate markers of atherosclerosis, and lipoprotein metabolism were evaluated in a 12 month prospective study. METHODS AND
resultsTreatment-naive HIV patients were recruited into one of three groups: untreated HIV infection not likely to require initiation of antiretroviral therapy (ART) for at least 12 months; initiating treatment with non nucleoside reverse transcriptase inhibitor-containing ART regimen and initiating treatment with protease inhibitor-containing ART regimen. The patients underwent assessment of carotid intima-media thickness (cIMT), pulse wave velocity (PWV), brachial flow-mediated dilation (FMD) and variables of plasma lipoprotein metabolism at baseline and 12 months. The findings were compared with published values for age and sex matched HIV-negative healthy subjects in a cross-sectional fashion. cIMT and FMD were lower while PWV was higher in HIV-patients compared with HIV-negative individuals; none of the markers changed significantly during 12 months follow up. HIV patients had hypoalphalipoproteinemia and elevated plasma levels of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein. The only significant changes in lipid-related variables were elevation of total cholesterol and triglycerides in patients treated with PI-containing regimen and elevation of plasma LCAT levels in patients treated with NNRTI-containing regimen. The ability of whole and apoB-depleted plasma to effect cholesterol efflux was not impaired in all three groups.
conclusionsThis study did not find evidence for rapid progression of subclinical atherosclerosis and deterioration of dyslipidaemia in HIV patients within 1 year.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.