ArticleThe American journal of cardiology2013
Relation of outbursts of anger and risk of acute myocardial infarction.
Article in The American journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Outbursts of anger as a trigger of acute cardiovascular events: a systematic review and meta-analysis.European heart journal · 2014Pooled it
- The Effects of Heart Rate Variability (HRV) Biofeedback on HRV Reactivity and Recovery During and After Anger Recall Task for Patients with Coronary Artery Disease.Applied psychophysiology and biofeedback · 2022Trial
- Stress and Acute Coronary Syndrome.Cardiology research · 2025Review
- Integrating Emotional Stress and Lipid Lowering in Cardiovascular Disease Management: The Future of Precision Cardiovascular Prevention.Journal of clinical medicine · 2025Article
- 2023 TAMIS/TSOC/TACVPR Consensus Statement for Patients with Acute Myocardial Infarction Rehabilitation.Acta Cardiologica Sinica · 2023Article
- A Pilot Study of Neurobiological Mechanisms of Stress and Cardiovascular Risk.Medical research archives · 2023Article
- Anger frequency and risk of cardiovascular morbidity and mortality.European heart journal open · 2022Article
- Depression-, Anxiety-, and Anger and Cognitive Functions: Findings From a Longitudinal Prospective Study.Frontiers in psychiatry · 2021Article
- Sociopolitical stress and acute cardiovascular disease hospitalizations around the 2016 presidential election.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Relation of outbursts of anger and the acute risk of placental abruption: A case-crossover study.Paediatric and perinatal epidemiology · 2019Article
- [Influence of gender on protective and vulnerability factors, adherence and quality of life in patients with cardiovascular disease].Atencion primaria · 2019Observational
- Associations of perceived stress and state anger with symptom burden and functional status in patients with heart failure.Psychology & health · 2019Article
- Emotional Processing In Patients with Ischemic Heart Diseases.Open access Macedonian journal of medical sciences · 2018Article
- Sex differences in cardiovascular disease - Impact on care and outcomes.Frontiers in neuroendocrinology · 2017Review
- Behavioral, emotional and neurobiological determinants of coronary heart disease risk in women.Neuroscience and biobehavioral reviews · 2017Review
- Psychological Aspects of Cardiac Care and Rehabilitation: Time to Wake Up to Sleep?Current cardiology reports · 2015Review
- Hostility and physiological responses to acute stress in people with type 2 diabetes.Psychosomatic medicine · 2015Article
- Brain disorders and the biological role of music.Social cognitive and affective neuroscience · 2015Review
- Brain Correlates of Mental Stress-Induced Myocardial Ischemia.Psychosomatic medicineArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
The aim of the present study was to explore the association between outbursts of anger and acute myocardial infarction (AMI) risk. Outbursts of anger are associated with an abrupt increase in cardiovascular events; however, it remains unknown whether greater levels of anger intensity are associated with greater levels of AMI risk or whether potentially modifiable factors can mitigate the short-term risk of AMI. We conducted a case-crossover analysis of 3,886 participants from the multicenter Determinants of Myocardial Infarction Onset Study, who were interviewed during the index hospitalization for AMI from 1989 to 1996. We compared the observed number and intensity of anger outbursts in the 2 hours preceding AMI symptom onset with its expected frequency according to each patient's control information, defined as the number of anger outbursts in the previous year. Of the 3,886 participants in the Determinants of Myocardial Infarction Onset Study, 1,484 (38%) reported outbursts of anger in the previous year. The incidence rate of AMI onset was elevated 2.43-fold (95% confidence interval 2.01 to 2.90) within 2 hours of an outburst of anger. The association was consistently stronger with increasing anger intensities (p trend <0.001). In conclusion, the risk of experiencing AMI was more than twofold greater after outbursts of anger compared with at other times, and greater intensities of anger were associated with greater relative risks. Compared with nonusers, regular β-blocker users had a lower susceptibility to heart attacks triggered by anger, suggesting that some drugs might lower the risk from each anger episode.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.