ArticleThe Annals of thoracic surgery2013
Favorable outcomes for multidrug and extensively drug resistant tuberculosis patients undergoing surgery.
Article in The Annals of thoracic surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Comorbidities and treatment outcomes in multidrug resistant tuberculosis: a systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis.Antimicrobial agents and chemotherapy · 2015Trial
- The Trend, Characteristics and Treatment Outcomes in Patients with Tuberculosis Undergoing Thoracic Surgery in the Kyrgyz Republic between 2017 and 2021.Tropical medicine and infectious disease · 2023Article
- Prevention of bronchial fistulas after pneumonectomies for selected cavitary drug resistant lung tuberculosis.Frontiers in surgery · 2023Article
- Adjunctive surgery versus medical treatment among patients with cavitary multidrug-resistant tuberculosis.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2021Article
- Characteristics and Treatment Outcomes of Patients with Tuberculosis Receiving Adjunctive Surgery in Uzbekistan.International journal of environmental research and public health · 2021Article
- Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections.Nature communications · 2021Observational
- Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Article
- Tuberculosis: mother of thoracic surgery then and now, past and prospectives: a review.Journal of thoracic disease · 2018Review
- A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis.The European respiratory journal · 2018Article
- Pulmonary resection in the treatment of multidrug-resistant tuberculosis: A case series.Medicine · 2017Article
- Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis.Antimicrobial agents and chemotherapy · 2017Article
- Extensively drug-resistant tuberculosis in India: Current evidence on diagnosis & management.The Indian journal of medical research · 2017Review
- Clinical outcomes for multi- and extensively drug resistant tuberculosis patients with adjunctive resectional lung surgery in Beijing, China.Journal of thoracic disease · 2017Article
- Role of Surgery in the Diagnosis and Management of Tuberculosis.Microbiology spectrum · 2017Review
- Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2017Review
- Is duration of preoperative anti-tuberculosis treatment a risk factor for postoperative relapse or non-healing of spinal tuberculosis?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Article
- The Role of Video-Assisted Thoracoscopic Therapeutic Resection for Medically Failed Pulmonary Tuberculosis.Medicine · 2016Observational
- Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis.Emerging infectious diseases · 2015Article
- Map the gap: missing children with drug-resistant tuberculosis.Public health action · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundNew approaches are needed in the treatment of multidrug-resistant and extensively drug-resistant pulmonary tuberculosis (M/XDR-PTB). We evaluated the role of adjunctive surgical therapy in the treatment of M/XDR-PTB in the setting of directly observed treatment strategy (DOTS)-Plus implementation.
methodsWe conducted an observational cohort study consisting of M/XDR-PTB patients who underwent thoracic surgery at the National Tuberculosis Center in Tbilisi, Georgia between October 2008 and February 2011. Indications for surgery included presence of M/XDR-PTB, localized pulmonary disease, fit to undergo surgery, and either medical treatment failure or such extensive drug resistance that failure was likely. Second-line anti-tuberculosis medical therapy was administered per World Health Organization (WHO) recommendations.
resultsSeventy-five patients (51 MDR, 24 XDR) with PTB underwent adjunctive thoracic surgery. Median age was 30 years and average duration of preoperative M/XDR-PTB medical therapy was 342 days. The following surgical procedures were performed: pneumonectomy (11%), lobectomy (54%), and segmentectomy (35%). Mean postoperative follow-up time was 372 days. Of 72 patients with evaluable outcomes, 59 (82%) had favorable outcomes including 90% of MDR and 67% of XDR-TB patients. There was no postoperative mortality; postoperative complications occurred in 7 patients (9%). Risk factors for poor treatment outcomes in univariate analysis included bilateral disease, XDR, increasing effective drugs received, positive preoperative sputum culture, and major postoperative surgical complication.
conclusionsPatients with M/XDR-PTB undergoing adjunctive thoracic surgery had high rates of favorable outcomes, no surgical-related mortality, and low rates of complications. Adjunctive surgery appears to play an important role in the treatment of select patients with M/XDR-PTB.
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