Trial reportOphthalmology2013
Improving function in age-related macular degeneration: a randomized clinical trial.
Trial report in Ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Self-management interventions for quality of life in adults with visual impairment.The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- Environmental and behavioural interventions for reducing physical activity limitation and preventing falls in older people with visual impairment.The Cochrane database of systematic reviews · 2020Pooled it
- Low vision rehabilitation for better quality of life in visually impaired adults.The Cochrane database of systematic reviews · 2020Pooled it
- Occupational Therapy Interventions to Improve Reading Performance of Older Adults With Low Vision: A Systematic Review.The American journal of occupational therapy : official publication of the American Occupational Therapy AssociationPooled it
- Interventions Within the Scope of Occupational Therapy Practice to Improve Performance of Daily Activities for Older Adults With Low Vision: A Systematic Review.The American journal of occupational therapy : official publication of the American Occupational Therapy AssociationPooled it
- Trial
- Low vision depression prevention trial in age-related macular degeneration: a randomized clinical trial.Ophthalmology · 2014Trial
- Vision-Related Patient-Reported Outcomes in Randomized Controlled Trials of Age-Related Macular Degeneration: A Systematic Review.Ophthalmology science · 2026Review
- Stargardt's Connected Research Network Inaugural Meeting: Landscape Review and Horizon Scanning of Stargardt Disease.Translational vision science & technology · 2025Review
- Rasch analysis and targeting assessment of the teach-CVI survey tool in a cohort of CVI patients.Frontiers in ophthalmology · 2024Article
- Health Management Service Models for the Elderly with Visual Impairment: A Scoping Review.Journal of multidisciplinary healthcare · 2024Article
- Visual Impairment and Mental Health: Unmet Needs and Treatment Options.Clinical ophthalmology (Auckland, N.Z.) · 2020Review
- Domains of health-related quality of life in age-related macular degeneration: a qualitative study in the Chinese cultural context.BMJ open · 2018Article
- Head-Mounted Display Technology for Low-Vision Rehabilitation and Vision Enhancement.American journal of ophthalmology · 2017Review
- Patient-Centered Outcome Measures to Assess Functioning in Randomized Controlled Trials of Low-Vision Rehabilitation: A Review.The patient · 2017Review
- Anxiety and depression in patients with advanced macular degeneration: current perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development.Clinical ophthalmology (Auckland, N.Z.) · 2015Review
- Longitudinal observation, evaluation and interpretation of coping with mental (emotional) health in low vision rehabilitation using the Dutch ICF Activity Inventory.Health and quality of life outcomes · 2014Observational
- Problem-Solving Therapy in the Elderly.Current treatment options in psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
purposeTo compare the efficacy of problem-solving therapy (PST) with supportive therapy (ST) to improve targeted vision function (TVF) in age-related macular degeneration (AMD).
designSingle-masked, attention-controlled, randomized clinical trial with outcome assessments at 3 months (main trial endpoint) and 6 months (maintenance effects).
participantsPatients with AMD (n = 241) attending retina practices.
interventionsWhereas PST uses a structured problem-solving approach to reduce vision-related task difficulty, ST is a standardized attention-control treatment.
main outcome measuresWe assessed TVF, the 25-item National Eye Institute Vision Function Questionnaire plus Supplement (NEI VFQ), the Activities Inventory (AI), and vision-related quality of life (QoL).
resultsThere were no between-group differences in TVF scores at 3 (P = 0.47) or 6 (P = 0.62) months. For PST subjects, mean ± standard deviation TVF scores improved from 2.71±0.52 at baseline to 2.18±0.88 at 3 months (P = 0.001) and were 2.18±0.95 at 6 months (change from 3 to 6 months, P = 0.74). For ST subjects, TVF scores improved from 2.73±0.52 at baseline to 2.14±0.96 at 3 months (P = 0.001) and were 2.15±0.96 at 6 months (change from 3 to 6 months, P = 0.85). Similar proportions of PST and ST subjects had less difficulty performing a TVF goal at 3 months (77.4% vs 78.6%, respectively; P = 0.83) and 6 months (76.2% vs 79.1%, respectively; P = 0.61). There were no changes in the NEI VFQ or AI. Vision-related QoL improved for PST relative to ST subjects at 3 months (F(4, 192) = 2.46; P = 0.05) and at 6 months (F(4, 178) = 2.55; P = 0.05). The PST subjects also developed more adaptive coping strategies than ST subjects.
conclusionsWe found that PST was not superior to ST at improving vision function in patients with AMD, but that PST improved their vision-related QoL. Despite the benefits of anti-vascular endothelial growth factor treatments, AMD remains associated with disability, depression, and diminished QoL. This clinical reality necessitates new rehabilitative interventions to improve the vision function and QoL of older persons with AMD. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any of the materials discussed in this article.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.