ArticleParasites & vectors2013
Hepatic stellate cells increase in Toxoplasma gondii infection in mice.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Endogenous cathelicidin protects againstInfection and immunity · 2026Article
- Pathological study and molecular detection of zoonotic diseases in small ruminants at slaughterhouses in Mymensingh, Bangladesh.Veterinary world · 2022Article
- Experimental infection of Mongolian gerbils withVeterinary research forum : an international quarterly journal · 2022Article
- Activity of isoflavone biochanin A in chronic experimental toxoplasmosis: impact on inflammation.Parasitology research · 2022Article
- Seroprevalence ofVeterinary world · 2022Article
- Histopathological, Immunohistochemical and Biochemical Studies of Murine Hepatosplenic Tissues Affected by Chronic Toxoplasmosis.Journal of parasitology research · 2022Article
- Prevalence ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- microRNA-155 Expression and Butyrylcholinesterase Activity in the Liver Tissue of Mice Infected with Toxoplasma gondii (Avirulent and Virulent Strains).Acta parasitologica · 2021Article
- T. gondii infection induces IL-1R dependent chronic cachexia and perivascular fibrosis in the liver and skeletal muscle.Scientific reports · 2020Article
- IL-1R Regulates Disease Tolerance and Cachexia inJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Role of stellate cells in hepatic echinococcosis in cattle.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2019Article
- Disease Tolerance inFrontiers in cellular and infection microbiology · 2019Review
- Congenital Transmission ofFrontiers in veterinary science · 2019Article
- Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China.Epidemiology and infection · 2017Article
- Toxoplasma gondii Infection and Chronic Liver Diseases: Evidence of an Association.Tropical medicine and infectious disease · 2016Article
- Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection.Parasites & vectors · 2016Article
- Article
- Toxoplasmosis complications and novel therapeutic synergism combination of diclazuril plus atovaquone.Frontiers in microbiology · 2014Article
- Adhesion of pancreatic cancer cells in a liver-microvasculature mimicking coculture correlates with their propensity to form liver-specific metastasis in vivo.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToxoplasma gondii is a ubiquitous protozoan parasite that can infect humans and animals. The severity of toxoplasmosis varies according to the immune status of the individual, parasite strain, and host species. In mammalian species, it has been observed that severe lesions of acute toxoplasmosis form in visceral organs such as the liver, lung, and spleen. Some epidemiological studies have reported an association of T. gondii infection with liver cirrhosis.
methodsAcute infection was induced in fifteen 30-day-old normal Swiss albino mice. The mice were infected by intraperitoneal inoculation of 5000 T. gondii RH strain tachyzoites. The mice were sacrificed in groups of 5 at 2, 4, and 6 days after inoculation. Another group of 5 mice were used as the controls. Anti-glial fibrillary acidic protein (GFAP) and anti-T. gondii antibodies were used to compare GFAP-immunoreactive cells and anti-T. gondii-immunopositive areas in the liver between the T. gondii-infected groups and the healthy controls, respectively.
resultsThere was a significant correlation between the numbers of GFAP-positive hepatic stellate cells (HSCs) when they were compared with T. gondii antigen immunostaining (p < 0.05). The amount of T. gondii immunostaining increased significantly with the increase in the number of HSCs.
conclusionsThere is a significant relationship between the number of HSCs and T. gondii antigens, which may represent an active role of HSCs in liver pathology and the pathobiology of T. gondii-related hepatitis.
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