ReviewAnnual review of nutrition2013
Vitamin E trafficking in neurologic health and disease.
Review in Annual review of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03797222 (Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome
Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Progressive nonambulatory tetraparesis and cerebellar signs in a 6-year-old spayed female Shiba Inu dog with normal brain MRI.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- Mitochondria as a therapeutic target in neurodegeneration caused by hypoxia and ischemia during the perinatal period.Pharmacological reports : PR · 2026Review
- Effects of pearl millet diet on serum micronutrient status, mental health and meta-cognitive skills in athletes: a randomised controlled trial.Discover mental health · 2025Article
- The Oxidative Stress in Epilepsy-Focus on Melatonin.International journal of molecular sciences · 2024Review
- Brain Trauma and the Secondary Cascade in Humans: Review of the Potential Role of Vitamins in Reparative Processes and Functional Outcome.Behavioral sciences (Basel, Switzerland) · 2023Review
- Vitamin E: Where Are We Now in Vascular Diseases?Life (Basel, Switzerland) · 2022Review
- α-Tocomonoenol Is Bioavailable in Mice and May Partly Be Regulated by the Function of the Hepatic α‑Tocopherol Transfer Protein.Molecules (Basel, Switzerland) · 2020Article
- Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain.The Journal of biological chemistry · 2020Article
- Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency.iScience · 2019Article
- The Effectiveness of Vitamin E Treatment in Alzheimer's Disease.International journal of molecular sciences · 2019Review
- Vitamin E Metabolic Effects and Genetic Variants: A Challenge for Precision Nutrition in Obesity and Associated Disturbances.Nutrients · 2018Review
- Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Review
- Article
- Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism.Free radical biology & medicine · 2017Article
- Lithium Accumulates in Neurogenic Brain Regions as Revealed by High Resolution Ion Imaging.Scientific reports · 2017Article
- Complexity of vitamin E metabolism.World journal of biological chemistry · 2016Review
- A Plasma α-Tocopherome Can Be Identified from Proteins Associated with Vitamin E Status in School-Aged Children of Nepal.The Journal of nutrition · 2015Article
- α-Tocopherol Is Well Designed to Protect Polyunsaturated Phospholipids: MD Simulations.Biophysical journal · 2015Article
- Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics.Journal of lipid research · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin E was identified almost a century ago as a botanical compound necessary for rodent reproduction. Decades of research since then established that of all members of the vitamin E family, α-tocopherol is selectively enriched in human tissues, and it is essential for human health. The major function of α-tocopherol is thought to be that of a lipid-soluble antioxidant that prevents oxidative damage to biological components. As such, α-tocopherol is necessary for numerous physiological processes such as permeability of lipid bilayers, cell adhesion, and gene expression. Inadequate levels of α-tocopherol interfere with cellular function and precipitate diseases, notably ones that affect the central nervous system. The extreme hydrophobicity of α-tocopherol poses a serious thermodynamic barrier for proper distribution of the vitamin to target tissues and cells. Although transport of the vitamin shares some steps with that of other lipids, selected tissues evolved dedicated transport mechanisms involving the α-tocopherol transfer protein (αTTP). The critical roles of this protein and its ligand are underscored by the debilitating pathologies that characterize human carriers of mutations in the TTPA gene.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.