ArticleAmyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis2013
Loss of gastric interstitial cells of Cajal in patients with hereditary transthyretin amyloidosis.
Article in Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv).Orphanet journal of rare diseases · 2025Observational
- Implications of Extra-cardiac Disease in Patient Selection for Heart Transplantation: Considerations in Cardiac Amyloidosis.Cardiac failure review · 2023Review
- Fecal calprotectin levels are elevated in transthyretin amyloidosis patients with gastrointestinal manifestations.Medicine · 2020Observational
- Diagnosis and treatment of gastrointestinal dysfunction in hereditary TTR amyloidosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Glial cells in familial amyloidotic polyneuropathy.Acta neuropathologica communications · 2014Article
- Post hoc analysis of nutritional status in patients with transthyretin familial amyloid polyneuropathy: impact of tafamidis.Neurology and therapy · 2014Article
- Cellular and molecular mechanism study of declined intestinal transit function in the cholesterol gallstone formation process of the guinea pig.Experimental and therapeutic medicine · 2014Article
- THAOS: gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease.Orphanet journal of rare diseases · 2014Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHereditary transthyretin (TTR) amyloidosis is a systemic neuropathic disorder caused by TTR gene mutations. Gastrointestinal complications are common and the underlying mechanisms remain unclear. The interstitial cells of Cajal (ICC) function as pacemaker cells in the gastrointestinal tract and are important for gastrointestinal motility. The aim of this study was to investigate the densities of gastric ICC and nerves in patients with TTR amyloidosis compared to non-amyloidosis controls.
methodsAntral wall autopsy specimens from 11 Japanese ATTR V30M patients and 10 controls were analyzed with immunohistochemistry and computerized analysis. Antibodies to c-Kit and TMEM16A were used to assess ICC and an antibody to PGP 9.5 was used to assess nervous tissue. The study was approved by a Japanese ethical committee.
resultsThe densities of c-Kit-immunoreactive (IR) ICC were significantly lower in the circular and longitudinal muscle layers of patients compared to controls (p = 0.004 for both). Equivalent results were found for TMEM16A-IR ICC. There were no significant differences in PGP 9.5-IR cells in the circular or longitudinal muscle layers between patients and controls (p = 0.173 and 0.099, respectively).
conclusionsA loss of gastrointestinal ICC may be an important factor for the digestive disturbances in hereditary TTR amyloidosis.
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