ReviewCurrent molecular medicine2013
MicroRNA regulation and role in stem cell maintenance, cardiac differentiation and hypertrophy.
Review in Current molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- 3'UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation.The EMBO journal · 2026Article
- The Essential Function of miR-5739 in Embryonic Muscle Development.International journal of stem cells · 2023Article
- Article
- METTL1-mediated mStem cell research & therapy · 2020Article
- NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.In vitro cellular & developmental biology. Animal · 2020Article
- microRNAs Regulating Human and Mouse Naïve Pluripotency.International journal of molecular sciences · 2019Article
- Nucleoporin insufficiency disrupts a pluripotent regulatory circuit in a pro-arrhythmogenic stem cell line.Scientific reports · 2019Article
- Review
- Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells.Molecular cell · 2018Article
- MicroRNA Changes in Firefighters.Journal of occupational and environmental medicine · 2018Article
- Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise.Cold Spring Harbor perspectives in medicine · 2018Review
- Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathy.Advances in experimental medicine and biology · 2018Article
- Stem Cell-Derived Exosomes, Autophagy, Extracellular Matrix Turnover, and miRNAs in Cardiac Regeneration during Stem Cell Therapy.Stem cell reviews and reports · 2017Review
- Inhibition of miR-302 Suppresses Hypoxia-Reoxygenation-Induced H9c2 Cardiomyocyte Death by Regulating Mcl-1 Expression.Oxidative medicine and cellular longevity · 2017Article
- Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy.Scientific reports · 2016Article
- MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b.Frontiers in physiology · 2016Article
- Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives.Stem cells international · 2016Review
- Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation.Tissue engineering. Part B, Reviews · 2015Review
- Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- MicroRNAs and Cardiac Regeneration.Circulation research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There are currently 1527 known microRNAs (miRNAs) in human, each of which may regulate hundreds or thousands of target genes. miRNA expression levels vary between cell types; for example, miR- 302 and miR-290 families are highly enriched in embryonic stem cells, while miR-1 is a muscle specific miRNA. miRNA biosynthesis and function are highly regulated and this regulation may be cell type specific. The processing enzymes and factors that recognize features in sequence and secondary structure of the miRNA play key roles in regulating the production of mature miRNA. Mature miRNA enriched in stem cells control stem cell self-renewal as well as their differentiation. Though specific miRNAs have been shown to control differentiation towards various lineages such as neural or skin cells, some of the most well characterized miRNAs have been found in promoting the formation of cardiac cells. In addition, miRNAs also play a critical role in cardiomyocyte hypertrophy, especially in a pathological context. Such miRNAs are predicted to be therapeutic targets for treating cardiovascular diseases. In this review we will discuss how miRNAs act to maintain the stem cell state and also explore the current knowledge of the mechanisms that regulate miRNAs. Furthermore, we will discuss the emerging roles of miRNAs using cardiomyocyte differentiation and maturation as a paradigm. Emphasis will also be given on some of the less ventured areas such as the role of miRNAs in the physiological maturation of cardiomyocytes. These potentially beneficial miRNAs are likely to improve cardiac function in both in vivo and in vitro settings and thus provide additional strategy to treat heart diseases and more importantly serve as a good model for understanding cardiomyocyte maturation in vitro.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.