ArticleJournal of the American Chemical Society2013
DNA branch migration reactions through photocontrollable toehold formation.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Single DNA hairpin nanowire based on self-hybridization chain reaction for sensitive ATP detection.Science and technology of advanced materials · 2026Article
- Hierarchical core-shell DNA condensates enable programmable information storage and encryption.Nature communications · 2025Article
- DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes.Nature communications · 2025Article
- Signal amplified colorimetric nucleic acid detection based on autocatalytic hairpin assembly.RSC advances · 2024Article
- Light-controlled growth of DNA organelles in synthetic cells.Interface focus · 2023Article
- PhotocleavableChemical reviews · 2023Review
- Expanding Catch and Release DNA Decoy (CRDD) Technology with Pyrimidine Mimics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- DNA Strand Displacement Driven by Host-Guest Interactions.Journal of the American Chemical Society · 2022Article
- Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers.Angewandte Chemie (International ed. in English) · 2022Article
- Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Article
- Programmable allosteric DNA regulations for molecular networks and nanomachines.Science advances · 2022Article
- A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection.Theranostics · 2022Article
- Controllable DNA strand displacement by independent metal-ligand complexation.Chemical science · 2021Article
- DNA Transformations for Diagnosis and Therapy.Advanced functional materials · 2021Review
- Nucleic Acids Analysis.Science China. Chemistry · 2021Review
- Multiple Light Control Mechanisms in ATP-Fueled Non-equilibrium DNA Systems.Angewandte Chemie (International ed. in English) · 2020Article
- Near-infrared light-activated membrane fusion for cancer cell therapeutic applications.Chemical science · 2020Article
- Click and photo-release dual-functional nucleic acid nanostructures.Chemical communications (Cambridge, England) · 2019Article
- Entropy-driven DNA logic circuits regulated by DNAzyme.Nucleic acids research · 2018Article
- DNA-Based Dynamic Reaction Networks.Trends in biochemical sciences · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Strand displacement cascades are commonly used to make dynamically assembled structures. Particularly, the concept of "toehold-mediated DNA branch migration reactions" has attracted considerable attention in relation to dynamic DNA nanostructures. However, it is a challenge to obtain and control the formation of pure 1:1 ratio DNA duplexes with toehold structures. Here, for the first time, we report a photocontrolled toehold formation method, which is based on the photocleavage of 2-nitrobenzyl linker-embedded DNA hairpin precursor structures. UV light irradiation (λ ≈ 365 nm) of solutions containing these DNA hairpin structures causes the complete cleavage of the nitrobenzyl linker, and pure 1:1 DNA duplexes with toehold structures are easily formed. Our experimental results indicate that the amount of toehold can be controlled by simply changing the dose of UV irradiation and that the resulting toehold structures can be used for subsequent toehold-mediated DNA branch migration reactions, e.g., DNA hybridization chain reactions. This newly established method will find broad application in the construction of light-powered, controllable, and dynamic DNA nanostructures or large-scale DNA circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.