ReviewEnvironmental health : a global access science source2013
PM2.5, oxidant defence and cardiorespiratory health: a review.
Review in Environmental health : a global access science source, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Current risk factors for male infertility and semen parameters: an umbrella review of systematic reviews and meta-analyses.Asian journal of andrology · 2026Pooled it
- Association between exposure to ambient air pollution and semen quality in adults: a meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Exposure to traffic-related air pollution during physical activity and acute changes in blood pressure, autonomic and micro-vascular function in women: a cross-over study.Particle and fibre toxicology · 2014Trial
- The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases.World journal of otorhinolaryngology - head and neck surgery · 2026Review
- Ambient Air Pollution Exposure and Mortality in the Pulmonary Hypertension Association Registry.Annals of the American Thoracic Society · 2025Article
- Particulate matter exposure induces pulmonary TRedox biology · 2025Article
- Overweight and obesity trends and association with household wealth index among children aged 5 to 19 years in Ethiopia a multilevel analysis of 2016 EDHS data.Scientific reports · 2025Article
- Environmental pollutants and phosphoinositide signaling in autoimmunity.Journal of hazardous materials · 2024Review
- Mitigation strategies to reduce particulate matter concentrations in civil engineering laboratories.Environmental science and pollution research international · 2024Article
- Scanning ion conductance microscopy reveals differential effect of PMAnalytical and bioanalytical chemistry · 2023Article
- Associations between Household Solid Fuel Use, Obesity, and Cardiometabolic Health in China: A Cohort Study from 2011 to 2018.International journal of environmental research and public health · 2023Article
- Rural-Urban Disparities in Multimorbidity Associated With Climate Change and Air Pollution: A Longitudinal Analysis Among Chinese Adults Aged 45.Innovation in aging · 2023Article
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Unequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA.Nature communications · 2022Article
- PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress.Oxidative medicine and cellular longevity · 2022Review
- Open questions on transition metals driving secondary thermal processes in atmospheric aerosols.Communications chemistry · 2021Article
- The critical role of epigenetic mechanism in PMGenes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Review
- Evaluating the influence of land use and land cover change on fine particulate matter.Scientific reports · 2021Article
- Development and evaluation of air pollution-linked quality of life (AP-QOL) questionnaire: insight from two different cohorts.Environmental science and pollution research international · 2021Article
- Effects of PM Exposure on the Methylation of Clock Genes in a Population of Subjects with Overweight or Obesity.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airborne fine particle mass concentrations (PM2.5) are used for ambient air quality management worldwide based in part on known cardiorespiratory health effects. While oxidative stress is generally thought to be an important mechanism in determining these effects, relatively few studies have specifically examined how oxidant defence may impact susceptibility to particulate air pollution. Here we review studies that explore the impact of polymorphisms in anti-oxidant related genes or anti-oxidant supplementation on PM2.5-induced cardiorespiratory outcomes in an effort to summarize existing evidence related to oxidative stress defence and the health effects of PM2.5. Recent studies of PM-oxidative burden were also examined. In total, nine studies were identified and reviewed and existing evidence generally suggests that oxidant defence may modify the impact of PM2.5 exposure on various health outcomes, particularly heart rate variability (a measure of autonomic function) which was the most common outcome examined in the studies reviewed. Few studies examined interactions between PM2.5 and oxidant defence for respiratory outcomes, and in general studies focused primarily on acute health effects. Therefore, further evaluation of the potential modifying role of oxidant defence in PM2.5-induced health effects is required, particularly for chronic outcomes. Similarly, while an exposure metric that captures the ability of PM2.5 to cause oxidative stress may offer advantages over traditional mass concentration measurements, little epidemiological evidence is currently available to evaluate the potential benefits of such an approach. Therefore, further evaluation is required to determine how this metric may be incorporated in ambient air quality management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.