ArticleBMC evolutionary biology2013
The expression and evolution of virulence in multiple infections: the role of specificity, relative virulence and relative dose.
Article in BMC evolutionary biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Review
- Microsporidian coinfection reduces fitness of a fungal pathogen due to rapid host mortality.mBio · 2024Article
- Out of the 'host' box: extreme off-host conditions alter the infectivity and virulence of a parasitic bacterium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Polystyrene nanoplastics differentially influence the outcome of infection by two microparasites of the hostPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- The parasites of my rival are my friends.Frontiers in microbiology · 2023Article
- Review
- Sequential infection ofParasitology · 2021Article
- Disentangling non-specific and specific transgenerational immune priming components in host-parasite interactions.Proceedings. Biological sciences · 2020Article
- Genetic resistance and specificity in sister taxa of Daphnia: insights from the range of host susceptibilities.Parasites & vectors · 2019Article
- Assessment of parasite virulence in a natural population of a planktonic crustacean.BMC ecology · 2019Article
- Large and finite sample properties of a maximum-likelihood estimator for multiplicity of infection.PloS one · 2018Article
- The virulence-transmission relationship in an obligate killer holds under diverse epidemiological and ecological conditions, but where is the tradeoff?Ecology and evolution · 2017Article
- The impact of host sex on the outcome of co-infection.Scientific reports · 2017Article
- Coinfection outcome in an opportunistic pathogen depends on the inter-strain interactions.BMC evolutionary biology · 2017Article
- Trade-offs and mixed infections in an obligate-killing insect pathogen.The Journal of animal ecology · 2016Article
- The adaptive evolution of virulence: a review of theoretical predictions and empirical tests.Parasitology · 2016Review
- Host age modulates within-host parasite competition.Biology letters · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple infections of the same host by different strains of the same microparasite species are believed to play a crucial role during the evolution of parasite virulence. We investigated the role of specificity, relative virulence and relative dose in determining the competitive outcome of multiple infections in the Daphnia magna-Pasteuria ramosa host-parasite system.
resultsWe found that infections by P. ramosa clones (single genotype) were less virulent and produced more spores than infections by P. ramosa isolates (possibly containing multiple genotypes). We also found that two similarly virulent isolates of P. ramosa differed considerably in their within-host competitiveness and their effects on host offspring production when faced with coinfecting P. ramosa isolates and clones. Although the relative virulence of a P. ramosa isolate/clone appears to be a good indicator of its competitiveness during multiple infections, the relative dose may alter the competitive outcome. Moreover, spore counts on day 20 post-infection indicate that the competitive outcome is largely decided early in the parasite's growth phase, possibly mediated by direct interference or apparent competition.
conclusionsOur results emphasize the importance of epidemiology as well as of various parasite traits in determining the outcome of within-host competition. Incorporating realistic epidemiological and ecological conditions when testing theoretical models of multiple infections, as well as using a wider range of host and parasite genotypes, will enable us to better understand the course of virulence evolution.
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