ArticlePediatric rheumatology online journal2013
Pain experience in children with juvenile idiopathic arthritis treated with anti-TNF agents compared to non-biologic standard treatment.
Article in Pediatric rheumatology online journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- A systematic review of the psychosocial factors associated with pain in children with juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2023Pooled it
- Adolescents' experiences of fluctuating pain in musculoskeletal disorders: a qualitative systematic review and thematic synthesis.BMC musculoskeletal disorders · 2020Pooled it
- Pooled it
- Significant pain decrease in children with non-systemic Juvenile Idiopathic Arthritis treated to target: results over 24 months of follow up.Pediatric rheumatology online journal · 2023Trial
- Cognitive behavioral group intervention for pain and well-being in children with juvenile idiopathic arthritis: a study of feasibility and preliminary efficacy.Pediatric rheumatology online journal · 2015Trial
- C-C motif chemokine ligand 12 (CCL12) is a critical chemokine driving postoperative pain.Pain · 2026Article
- The interplay between pain and disease activity: personal models of pain beliefs and emotional representations in children and young people with juvenile idiopathic arthritis in a UK nationwide prospective inception cohort.Journal of pediatric psychology · 2025Article
- Unexpected Role of TNFα Signaling in the Resolution of Postoperative Pain in Mice.Journal of pain research · 2025Article
- Pain Interference in Juvenile Idiopathic Arthritis.The Journal of rheumatology · 2024Observational
- Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications.Rheumatology international · 2024Review
- Beliefs About Pain in Pediatric Inflammatory and Noninflammatory Chronic Musculoskeletal Conditions: A Scoping Review.Journal of pediatric psychology · 2023Article
- An explorative study on proteomic analyses related to inflammation and pain in children with juvenile idiopathic arthritis.BMC pediatrics · 2023Article
- Pain-coping scale for children and their parents: a cross-sectional study in children with musculoskeletal pain.Pediatric rheumatology online journal · 2023Article
- Musculoskeletal pain and its effect on daily activity and behaviour in Icelandic children and youths with juvenile idiopathic arthritis: a cross-sectional case-control study.Pediatric rheumatology online journal · 2022Article
- Drivers of non-zero physician global scores during periods of inactive disease in juvenile idiopathic arthritis.RMD open · 2022Article
- Pain sensitivity in young adults with juvenile idiopathic arthritis: a quantitative sensory testing study.Arthritis research & therapy · 2020Article
- Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis.Brain, behavior, and immunity · 2020Article
- Association of Anxiety With Pain and Disability but Not With Increased Measures of Inflammation in Adolescent Patients With Juvenile Idiopathic Arthritis.Arthritis care & research · 2020Article
- Treating juvenile idiopathic arthritis to target: what is the optimal target definition to reach all goals?Pediatric rheumatology online journal · 2020Article
- Validation and adaptation of a German screening tool to identify patients at risk of juvenile idiopathic arthritis.Rheumatology international · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-TNF agents have proven efficacy in children with severe juvenile idiopathic arthritis (JIA) who are unresponsive to standard therapy. Therefore pain reduction or elimination could be expected. The aim of this study was to compare the pain experience in children with JIA treated with anti-TNF agents (n = 41) or non-biologic standard treatment (n = 50).
methodsAll children completed a 2-week pain diary and, for children treated with anti-TNF agents, measures of pain-coping and pain-specific beliefs. Parents rated the child's level of functional disability. Clinical data were collected from the pediatric rheumatologists.
resultsNo significant differences were found between the anti-TNF group and non-biologic standard treatment group for average pain score, number of children with daily pain reported in the pain diary, or level of functional disability. Significantly more children in the anti-TNF group reported no pain at all. Children undergoing standard treatment had significantly higher disease activity. Significant differences were found between the high pain patients treated with anti-TNF agents and the rest of the anti-TNF group in regards to their pain-specific beliefs of disability and harm, and the pain-coping strategy of catastrophizing.
conclusionThese results indicate that a great proportion of children treated with anti-TNF agents respond well to the treatment in regards to disease activity and pain, but pain was still a problem for a subgroup of children though they were in remission with biological agents. More focus on pain management is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.