ArticleFrontiers in cellular neuroscience2013
Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prevalence and practices of immunofluorescent cell image processing: a systematic review.Frontiers in cellular neuroscience · 2023Pooled it
- Article
- Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury.Journal of neuroinflammation · 2019Article
- CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis.Brain, behavior, and immunity · 2019Review
- The Potential of Astrocytes as Immune Modulators in Brain Tumors.Frontiers in immunology · 2019Review
- Bidirectional modulation between infiltrating CD3Scientific reports · 2018Article
- Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird's Eye View.Frontiers in immunology · 2018Review
- Multiple sclerosis: an example of pathogenic viral interaction?Virology journal · 2017Review
- Neuroimmunological Implications of AQP4 in Astrocytes.International journal of molecular sciences · 2016Review
- Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10.European journal of immunology · 2015Article
- Interleukin-17 impedes Schwann cell-mediated myelination.Journal of neuroinflammation · 2014Article
- Neuronal and astrocytic interactions modulate brain endothelial properties during metabolic stresses of in vitro cerebral ischemia.Cell communication and signaling : CCS · 2014Article
- Imaging and monitoring astrocytes in health and disease.Frontiers in cellular neuroscience · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of astrocytes in the immune-mediated inflammatory response in the brain is more prominent than previously thought. Astrocytes become reactive in response to neuro-inflammatory stimuli through multiple pathways, contributing significantly to the machinery that modifies the parenchymal environment. In particular, astrocytic signaling induces the establishment of critical relationships with infiltrating blood cells, such as lymphocytes, which is a fundamental process for an effective immune response. The interaction between astrocytes and T-cells involves complex modifications to both cell types, which undergo micro-anatomical changes and the redistribution of their binding and secretory domains. These modifications are critical for different immunological responses, such as for the effectiveness of the T-cell response, for the specific infiltration of these cells and their homing in the brain parenchyma, and for their correct apposition with antigen-presenting cells (APCs) to form immunological synapses (ISs). In this article, we review the current knowledge of the interactions between T-cells and astrocytes in the context of immune-mediated inflammation in the brain, based on the micro-anatomical imaging of these appositions by high-resolution confocal microscopy and three-dimensional rendering. The study of these dynamic interactions using detailed technical approaches contributes to understanding the function of astrocytes in inflammatory responses and paves the way for new therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.