ArticleFrontiers in cellular neuroscience2013
Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ).Environment & health (Washington, D.C.) · 2025Article
- Neuronal chemokines: new insights into neuronal communication after injury.Neural regeneration research · 2023Article
- CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum.Development (Cambridge, England) · 2023Article
- The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System.International journal of molecular sciences · 2022Review
- Nociception-Dependent CCL21 Induces Dorsal Root Ganglia Axonal GrowthFrontiers in immunology · 2022Article
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- CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation.Molecular psychiatry · 2021Article
- Serine Proteases and Chemokines in Neurotrauma: New Targets for Immune Modulating Therapeutics in Spinal Cord Injury.Current neuropharmacology · 2021Review
- Lauric acid promotes neuronal maturation mediated by astrocytes in primary cortical cultures.Heliyon · 2020Article
- An update on Wnt signaling pathway in cancer.Translational cancer research · 2020Review
- CXCL1 and CXCL2 Inhibit the Axon Outgrowth in a Time- and Cell-Type-Dependent Manner in Adult Rat Dorsal Root Ganglia Neurons.Neurochemical research · 2019Article
- The canonical Wnt/β-catenin signaling pathway stimulates herpes simplex virus 1 productive infection.Virus research · 2018Article
- Necrotizing enterocolitis is associated with acute brain responses in preterm pigs.Journal of neuroinflammation · 2018Article
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- Potential Role for a β-Catenin Coactivator (High-Mobility Group AT-Hook 1 Protein) during the Latency-Reactivation Cycle of Bovine Herpesvirus 1.Journal of virology · 2017Article
- The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection.Virology · 2017Article
- CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5.Scientific reports · 2016Article
- β-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1.Journal of virology · 2016Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that growth factors [Neurotrophins (NT) and Hepatocyte Growth Factor (HGF)] signal through β-catenin during axon morphogenesis. HGF signaling promotes axon outgrowth and branching by inducing β-catenin phosphorylation at Y142 and transcriptional regulation of T-Cell Factor (TCF) target genes. Here, we asked which genes are regulated by HGF signaling during axon morphogenesis. An array screening indicated that HGF signaling elevates the expression of chemokines of the CC and CXC families. In line with this, CCL7, CCL20, and CXCL2 significantly increase axon outgrowth in hippocampal neurons. Experiments using blocking antibodies and chemokine receptor antagonists demonstrate that chemokines act downstream of HGF signaling during axon morphogenesis. In addition, qPCR data demonstrates that CXCL2 and CCL5 expression is stimulated by HGF through Met/b-catenin/TCF pathway. These results identify CC family members and CXCL2 chemokines as novel regulators of axon morphogenesis downstream of HGF signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.