ArticleThe Journal of infectious diseases2013
Fatal neurological respiratory insufficiency is common among viral encephalitides.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Cross-protection against St. Louis encephalitis virus and Usutu virus by West Nile virus convalescent plasma.Virology · 2025Article
- A case report of long-latency evoked diaphragm potentials after exposure to acute intermittent hypoxia in post-West Nile virus meningoencephalitis.Journal of neurophysiology · 2025Article
- An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections.Cell reports · 2018Article
- Death and gastrointestinal bleeding complicate encephalomyelitis in mice with delayed appearance of CNS IgM after intranasal alphavirus infection.The Journal of general virology · 2018Article
- Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters.Journal of neurovirology · 2017Article
- Modeling Powassan virus infection in Peromyscus leucopus, a natural host.PLoS neglected tropical diseases · 2017Article
- In Vivo Interrogation of Spinal Mechanosensory Circuits.Cell reports · 2016Article
- Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Autonomic deficit not the cause of death in West Nile virus neurological disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Article
- Emerging infections of the central nervous system.Current infectious disease reports · 2013Article
- Neurological approaches for investigating West Nile virus disease and its treatment in rodents.Antiviral research · 2013Review
- Catastrophic Case of West Nile Virus Rhombencephalitis in AIDS.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeurological respiratory insufficiency strongly correlates with mortality among rodents infected with West Nile virus (WNV), which suggests that this is a primary mechanism of death in rodents and possibly fatal West Nile neurological disease in human patients.
methodsTo explore the possibility that neurological respiratory insufficiency is a broad mechanism of death in cases of viral encephalitis, plethysmography was evaluated in mice infected with 3 flaviviruses and 2 alphaviruses. Pathology was investigated by challenging the diaphragm, using electromyography with hypercapnia and optogenetic photoactivation.
resultsAmong infections due to all but 1 alphavirus, death was strongly associated with a suppressed minute volume. Virally infected mice with a very low minute volume did not neurologically respond to hypercapnia or optogenetic photoactivation of the C4 cervical cord. Neurons with the orexin 1 receptor protein in the ventral C3-5 cervical cord were statistically diminished in WNV-infected mice with a low minute volume as compared to WNV-infected or sham-infected mice without respiratory insufficiency. Also, WNV-infected cells were adjacent to neurons with respiratory functions in the medulla.
conclusionsDetection of a common neurological mechanism of death among viral encephalitides creates opportunities to create broad-spectrum therapies that target relevant neurological cells in patients with types of viral encephalitis that have not been treatable in the past.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.