ArticleClinical journal of the American Society of Nephrology : CJASN2013
Relation between asymptomatic proteinase 3 antibodies and future granulomatosis with polyangiitis.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- ANCA testing strategies: A single centre experience over the past decade in a large teaching hospital in the Netherlands.PloS one · 2026Article
- Can we cure vasculitis?Current opinion in immunology · 2025Review
- Antineutrophil Cytoplasmic Antibodies (ANCAs): Role in Diagnosis, Disease Monitoring, and Prognosis.Journal of the American Society of Nephrology : JASN · 2025Review
- Exploring ANCA Pathogenicity in Ulcerative Colitis: A Case Report Highlighting the Risk of Progression to ANCA-Associated Vasculitis.European journal of case reports in internal medicine · 2025Article
- Infection is associated with increased risk of MPO- but not PR3-ANCA-associated vasculitis.Rheumatology (Oxford, England) · 2022Article
- Detection of PLA2R Autoantibodies before the Diagnosis of Membranous Nephropathy.Journal of the American Society of Nephrology : JASN · 2020Article
- ANCA-Associated Vasculitis in Inflammatory Bowel Disease.Digestive diseases and sciences · 2019Article
- Personalized Medicine in ANCA-Associated Vasculitis ANCA Specificity as the Guide?Frontiers in immunology · 2019Review
- Anti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis.Autoimmune diseases · 2017Article
- Prevention of rheumatic diseases: strategies, caveats, and future directions.Rheumatic diseases clinics of North America · 2014Review
- Increased serum free light chains precede the presentation of immunoglobulin light chain amyloidosis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease.Nature reviews. Rheumatology · 2014Review
- Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE.Nature reviews. Rheumatology · 2014Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe subclinical pathogenesis of granulomatosis with polyangiitis (GPA) has not been completely elucidated. Proteinase 3 (PR3) antibodies are strongly associated with GPA, but have not been evaluated before disease presentation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a retrospective case-control serum bank study in which PR3 antibodies and C-reactive protein (CRP) in up to three longitudinal serum samples for 27 GPA patients before diagnosis (1 day-19 years) were compared with 27 controls whose serum samples were matched for age, sex, and race. This study analyzed all patients with American College of Rheumatology criteria-confirmed disease identified in the Department of Defense electronic medical records between 1990 and 2008.
resultsA greater percentage of GPA patients had at least one elevated PR3 antibody level (≥6 U/ml) as well as at least one detectable PR3 antibody level (>1 U/ml) before diagnosis compared with matching controls (63% [17 of 27] versus 0% [0 of 27], P<0.001; and 85% [23 of 27] versus 4% [1 of 27], P<0.001, respectively). A greater percentage of GPA patients had a >1 U/ml per year rate of increase in PR3 antibody level compared with matching controls (62% [21 of 26] versus 0% [0 of 26], P<0.001). PR3 antibody more frequently became elevated before CRP (67% [12 of 18] versus 33% [6 of 18], P=0.04).
conclusionsSubclinical PR3 antibody presence, trajectory, and temporal relationship to CRP associates with the future diagnosis of GPA. This data set further elucidates the pathogenesis of GPA.
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