ArticleThe Journal of clinical endocrinology and metabolism2013
Complex rhythmicity and age dependence of growth hormone secretion are preserved in patients with acromegaly: further evidence for a present hypothalamic control of pituitary somatotropinomas.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Trial
- To test or not to test: what we have learnt from 50 years of dynamic testing in acromegaly.Pituitary · 2026Review
- Paradoxical GH increase after oral glucose load in subjects with and without acromegaly.Journal of endocrinological investigation · 2024Observational
- Systemic comorbidities of acromegaly in real-life experience: which difference among young and elderly patients?Endocrine · 2023Article
- Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry.Internal and emergency medicine · 2022Article
- Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity.The Journal of clinical endocrinology and metabolism · 2021Article
- Clinical presentation and management of acromegaly in elderly patients.Hormones (Athens, Greece) · 2021Article
- Acromegaly in the elderly patients.Endocrine · 2020Review
- Random Gh and Igf-I levels after transsphenoidal surgery for acromegaly: relation with long-term remission.Endocrine · 2020Article
- A Consensus Statement on acromegaly therapeutic outcomes.Nature reviews. Endocrinology · 2018Review
- Growth hormone: isoforms, clinical aspects and assays interference.Clinical diabetes and endocrinology · 2018Review
- "Micromegaly": an update on the prevalence of acromegaly with apparently normal GH secretion in the modern era.Pituitary · 2016Article
- Acromegaly in the elderly patient.Archives of endocrinology and metabolismReview
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Authors and funding
3 authors.
Funding
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Abstract
contextTraditionally, acromegaly is viewed as a disease resulting from GH hypersecretion from an autonomous pituitary somatotropinoma.
objectiveTo test the hypothesis that GH secretion in acromegaly is still subjected to normal hypothalamic control, we studied the daily rhythmicity of GH secretion in normal controls and patients with newly diagnosed, untreated acromegaly. DESIGN AND
settingThis was an observational inpatient study in the General Clinical Research Center at the University of Michigan. PATIENTS OR OTHER
participantsOne hundred four normal controls and 67 acromegalic patients were included in the study.
interventionThe intervention consisted of frequent blood sampling over 24 hours. MAIN OUTCOME MEASURE(S): We hypothesized that acromegalic patients would show rhythmicity, sexual dimorphism, and age-related decline of GH secretion similar to normal controls.
resultsBoth normal controls and the patients exhibited 3 major GH waves with the highest values at 12:00 pm, 5:00 pm, and 1:00 am (P < .001 for all). Both controls and patients exhibited a clear appearance of the nocturnal GH waves, irrespective of the gender (P < .001 for all). The amplitude of the maximal (nocturnal) GH secretory wave (1:00 am) as compared with the nadir GH secretion (9:00 am) was clearly different between the 2 groups, with a significantly smaller magnitude in acromegaly (P < .001). A subsequent subanalysis of both groups was performed separately for both genders. Similar to the entire groups, both controls and patients exhibited a clear appearance of the nocturnal GH waves, irrespective of the gender (P < .001 for all). Patients with clearly elevated GH values have shown an age-related decline of GH secretion (r = -0.35, P < .001), similar to controls.
conclusionsThe analysis of GH profiles in multiple patients with untreated acromegaly discloses the persistence of the hallmarks of the central control of GH regulation, ie, nictohemeral rhythmicity, sexual dimorphism, and an age-related decline of GH output.
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