ArticleHippocampus2013
Long-term effects of neonatal hippocampal lesions on novelty preference in monkeys.
Article in Hippocampus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Role of the Primate Perirhinal Cortex in Memory and Emotional Regulation: Ontogeny and Early Insults.Medical research archives · 2026Article
- Review
- Differential responses toward conditioned and unconditioned stimuli, but decreased hypothalamic-pituitary-adrenal axis responsiveness in neonatal hippocampal lesioned monkeys.Developmental cognitive neuroscience · 2022Article
- Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys.Behavioral neuroscience · 2018Article
- Article
- Intact perceptual ability, but impaired familiarity judgment, after neonatal perirhinal lesions in rhesus macaques.Developmental cognitive neuroscience · 2017Article
- Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior.Developmental cognitive neuroscience · 2017Review
- An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions.Developmental psychobiology · 2017Article
- Increased anxiety-like behaviors, but blunted cortisol stress response after neonatal hippocampal lesions in monkeys.Psychoneuroendocrinology · 2017Article
- Decreased functional connectivity in dorsolateral prefrontal cortical networks in adult macaques with neonatal hippocampal lesions: Relations to visual working memory deficits.Neurobiology of learning and memory · 2016Article
- Object and spatial memory after neonatal perirhinal lesions in monkeys.Behavioural brain research · 2016Article
- The development of object recognition memory in rhesus macaques with neonatal lesions of the perirhinal cortex.Developmental cognitive neuroscience · 2015Article
- Alterations of hippocampal projections in adult macaques with neonatal hippocampal lesions: a Diffusion Tensor Imaging study.NeuroImage · 2014Article
- Development of memory for spatial locations and object/place associations in infant rhesus macaques with and without neonatal hippocampal lesions.Journal of the International Neuropsychological Society : JINS · 2013Article
- Preclinical modeling of exposure to a global marine bio-contaminant: Effects of in utero Domoic acid exposure on neonatal behavior and infant memory.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In a recent longitudinal study to assess the development of incidental recognition memory processes in monkeys, we showed that the effects of neonatal hippocampal lesions did alter incidental recognition memory only when the animals reached the juvenile period (Zeamer et al., ). The current follow-up study tested whether this incidental memory loss was long-lasting, i.e., present in adulthood, or only transitory, due to functional compensation with further brain maturation. The same animals with neonatal hippocampal lesions and their sham-operated controls were re-tested in the visual paired-comparison task when they reached adulthood (48 months). The results demonstrated that, at least for easily discriminable color pictures of objects, the involvement of the hippocampus was only transitory, given that when re-tested as adults, animals with neonatal hippocampal lesions performed as well as sham-operated controls at all delays. Yet, significant recognition memory impairment was re-instated when the discriminability of the stimuli was made more difficult (black/white pictures of similar objects). The data demonstrate profound functional remodeling within the hippocampus and its interactions with different medial temporal lobe structures from the juvenile period to adulthood, which is substantiated by a parallel morphological maturation of hippocampal intrinsic circuits (Lavenex et al., ; Jabès et al., ).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.