ArticleJournal of hypertension2013
Sexual activity and function among middle-aged and older men and women with hypertension.
Article in Journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Sexual Dysfunction in Women with Hypertension: a Systematic Review and Meta-analysis.Current hypertension reports · 2019Pooled it
- Sexual function among controlled and uncontrolled hypertensive females receiving beta-blockers or ACEI/ARB and thiazides: a prospective randomized controlled study.Scientific reports · 2026Trial
- Blood Pressure, Sexual Activity, and Erectile Function in Hypertensive Men: Baseline Findings from the Systolic Blood Pressure Intervention Trial (SPRINT).The journal of sexual medicine · 2019Trial
- Blood Pressure, Sexual Activity, and Dysfunction in Women With Hypertension: Baseline Findings From the Systolic Blood Pressure Intervention Trial (SPRINT).The journal of sexual medicine · 2016Trial
- Antihypertensive medications and sexual function in women: baseline data from the SBP intervention trial (SPRINT).Journal of hypertension · 2016Trial
- Sexual Response Problems and Their Correlates Among Older Adults From the Sexual Well-Being (SWELL) Study in China: Multicenter Cross-Sectional Study.JMIR aging · 2025Article
- The 18-year risk of cancer, angioedema, insomnia, depression, and erectile dysfunction in association with antihypertensive drugs: post-trial analyses from ALLHAT-Medicare linked data.Frontiers in cardiovascular medicine · 2023Article
- Management of Hypertension with Female Sexual Dysfunction.Medicina (Kaunas, Lithuania) · 2022Review
- "Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial".Frontiers in cell and developmental biology · 2022Review
- Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds.Journal of clinical medicine · 2021Article
- Protective effects of irbesartan and benazepril against vaginal vascular remodeling and fibrosis in female spontaneously hypertensive rats.The Journal of international medical research · 2020Article
- The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review.Current urology · 2019Review
- Metabolic Syndrome and Sexual Function in Postmenopausal Women.The American journal of medicine · 2016Article
- Physical examination of the female cancer patient with sexual concerns: What oncologists and patients should expect from consultation with a specialist.CA: a cancer journal for clinicians · 2016Review
- Tolerability of Antihypertensive Medications in Older Adults.Drugs & aging · 2015Review
- α2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression.Psychoneuroendocrinology · 2015Article
- Sexual Function, Satisfaction, and Use of Aids for Sexual Activity in Middle-Aged Adults with Long-Term Physical Disability.Topics in spinal cord injury rehabilitation · 2015Article
- Article
- Associations between health and sexual lifestyles in Britain: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).Lancet (London, England) · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine the association of hypertension (HTN) and its treatment with sexual function in middle-aged and older adults.
methodsWe studied a nationally representative sample of community-residing adults aged 57-85 years (n = 3005) from the National Social Health, Life and Aging Project. Adults were categorized by HTN status (treated, untreated, and no HTN). Antihypertensive medication use was classified into calcium channel blocker; β-blocker; angiotensin-converting enzyme inhibitor/angiotensin receptor blocker; diuretic; and α-blocker. For each HTN and medication group, we determined the prevalence and adjusted odds of being sexually active and of having any sexual problem.
resultsAmong men, comparing treated HTN with untreated HTN and no HTN, sexual activity was less prevalent (66.5 vs. 75.9 vs.71.5%, P <0.01) and sexual problems were more prevalent (69.1 vs. 57.7 vs. 54.3%; P ≤ 0.01). There was no association between treated HTN and sexual activity [odds ratio, OR = 0.86 (95% confidence interval 0.51-1.45)] and a nonsignificant association between treated HTN and sexual problems [OR = 1.49 (0.94-2.37)]. Among women, the prevalence of sexual activity was lower in the treated and untreated HTN groups than the no HTN group (35.2 vs. 38.3 vs. 58.0%, P <0.01); the prevalence of sexual problems was similar (73.7 vs. 65.3 vs. 71.7%; P = 0.301). Women in the treated HTN [OR = 0.61 (0.39-0.95)] and untreated HTN [0.54 (0.30-0.96)] groups had a lower odds of sexual activity compared with no HTN. There were no significant associations between antihypertensive medication class and sexual activity or problems in men or women.
conclusionThe relationship between HTN and sexual health is different for older men and women. Prospective, comparative effectiveness trials are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.