ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Effect of healthy aging on renal vascular responses to local cooling and apnea.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Short-term exposure to ambient air pollutants increases the mortality risk of chronic kidney disease: a time-stratified case-crossover study in Zhejiang Province.BMC nephrology · 2026Article
- The role of age and sex in non-linear dilution adjustment of spot urine arsenic.BMC nephrology · 2024Article
- Physiological confounders of renal blood flow measurement.Magma (New York, N.Y.) · 2024Review
- Pressure-Natriuresis Response Is Diminished in Old Age.Frontiers in cardiovascular medicine · 2022Article
- Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging.Temperature (Austin, Tex.) · 2021Review
- Obstructive Sleep Apnea and Hypertension: A Review of the Relationship and Pathogenic Association.Cureus · 2020Review
- Attenuated Cardiovascular Responses to the Cold Pressor Test in Concussed Collegiate Athletes.Journal of athletic training · 2020Article
- Neural control of cardiovascular function in black adults: implications for racial differences in autonomic regulation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Review
- Mechanisms of altered renal sodium handling in age-related hypertension.American journal of physiology. Renal physiology · 2018Review
- Renal Hemodynamics During Sympathetic Activation Following Aerobic and Anaerobic Exercise.Frontiers in physiology · 2018Article
- Differential roles of caveolin-1 in ouabain-induced Na+/K+-ATPase cardiac signaling and contractility.Physiological genomics · 2016Article
- Ascorbic acid attenuates the pressor response to voluntary apnea in postmenopausal women.Physiological reports · 2015Article
- Chemoreflex physiology and implications for sleep apnoea: insights from studies in humans.Experimental physiology · 2015Review
- Do peripheral and/or central chemoreflexes influence skin blood flow in humans?Physiological reports · 2014Article
- β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling.American journal of physiology. Heart and circulatory physiology · 2014Article
- Sex differences in forearm vasoconstrictor response to voluntary apnea.American journal of physiology. Heart and circulatory physiology · 2014Article
- Obstructive sleep apnea and hypertension: an update.Hypertension (Dallas, Tex. : 1979) · 2014Review
- Evaluation of Phyllanthus emblica extract on cold pressor induced cardiovascular changes in healthy human subjects.Pharmacognosy research · 2014Article
- Forearm vascular responses to mental stress in healthy older adults.Physiological reports · 2013Article
- Effect of oxidative stress on sympathetic and renal vascular responses to ischemic exercise.Physiological reports · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sympathetically mediated renal vasoconstriction may contribute to the pathogenesis of hypertension in older adults, but empirical data in support of this concept are lacking. In 10 young (26 ± 1 yr) and 11 older (67 ± 2 yr) subjects, we quantified acute hemodynamic responses to three sympathoexcitatory stimuli: local cooling of the forehead, cold pressor test (CPT), and voluntary apnea. We hypothesized that all stimuli would increase mean arterial blood pressure (MAP) and renal vascular resistance index (RVRI) and that aging would augment these effects. Beat-by-beat MAP, heart rate (HR), and renal blood flow velocity (from Doppler) were measured in the supine posture, and changes from baseline were compared between groups. In response to 1°C forehead cooling, aging was associated with an augmented MAP (20 ± 3 vs. 6 ± 2 mmHg) and RVRI (35 ± 6 vs. 16 ± 9%) but not HR. In older adults, there was a positive correlation between the cold-induced pressor response and forehead pain (R = 0.726), but this effect was not observed in young subjects. The CPT raised RVRI in both young (56 ± 13%) and older (45 ± 8%) subjects, but this was not different between groups. Relative to baseline, end-expiratory apnea increased RVRI to a similar extent in both young (46 ± 14%) and older (41 ± 9%) subjects. During sympathetic activation, renal vasoconstriction occurred in both groups. Forehead cooling caused an augmented pressor response in older adults that was related to pain perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.