ArticleBritish journal of cancer2013
Body size in relation to incidence of subtypes of haematological malignancy in the prospective Million Women Study.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Body mass index and multiple myeloma: a systematic review and dose-response meta-analysis of prospective cohort studies.BMC cancer · 2026Pooled it
- Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis.Scientific reports · 2017Pooled it
- Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.Journal of the National Cancer Institute. Monographs · 2014Pooled it
- Environmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.International journal of cancer · 2026Article
- Causal relationships between body composition and hematological malignancies: a multivariable mendelian randomization analysis.Cancer causes & control : CCC · 2025Article
- Polycythaemia vera.Nature reviews. Disease primers · 2025Review
- Editorial: Obesity and cancer: the possible molecular links.Frontiers in cell and developmental biology · 2025Article
- Metformin for MPN: teaching an old drug new tricks.Blood advances · 2024Article
- The causal effect of adipose tissue on Hodgkin's lymphoma: two-sample Mendelian randomization study and validation.Frontiers in immunology · 2024Article
- Impact of Quantitative Computed Tomography-Based Analysis of Abdominal Adipose Tissue in Patients with Lymphoma.Hematology reports · 2023Article
- LEP promoter methylation in the initiation and progression of clonal cytopenia of undetermined significance and myelodysplastic syndrome.Clinical epigenetics · 2023Article
- The Microenvironment in Myeloproliferative Neoplasms.Hematology/oncology clinics of North America · 2021Review
- Role for Leptin and Leptin Receptors in Stem Cells During Health and Diseases.Stem cell reviews and reports · 2021Review
- Body Mass Index and Total Symptom Burden in Myeloproliferative Neoplasms Discovery of a U-shaped Association.Cancers · 2020Article
- Review
- Aetiology of Myeloproliferative Neoplasms.Cancers · 2020Review
- Modifiable Lifestyle and Medical Risk Factors Associated With Myeloproliferative Neoplasms.HemaSphere · 2020Article
- Genetically Determined Height and Risk of Non-hodgkin Lymphoma.Frontiers in oncology · 2019Article
- Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome.Haematologica · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGreater adiposity and height have been associated with increased risk of haematological malignancies. Associations for disease subtypes are uncertain.
methodsA cohort of 1.3 million middle-aged U.K. women was recruited in 1996-2001 and followed for 10 years on average. Potential risk factors were assessed by questionnaire. Death, emigration, and incident cancer were ascertained by linkage to national registers. Adjusted relative risks were estimated by Cox regression.
resultsDuring follow-up, 9162 participants were diagnosed with lymphatic or haematopoietic cancers. Each 10 kg m(-2) increase in body mass index was associated with relative risk of 1.20 (95% confidence interval: 1.13-1.28) for lymphoid and 1.37 (1.22-1.53) for myeloid malignancy (P=0.06 for heterogeneity); similarly, Hodgkin lymphoma 1.64 (1.21-2.21), diffuse large B-cell lymphoma 1.36 (1.17-1.58), plasma cell neoplasms 1.21 (1.06-1.39), acute myeloid leukaemia 1.47 (1.19-1.81), and myeloproliferative/myelodysplastic syndromes 1.32 (1.15-1.52). Each 10 cm increase in height was associated with relative risk of 1.21 (1.16-1.27) for lymphoid and 1.11 (1.02-1.21) for myeloid malignancy (P=0.07 for heterogeneity); similarly, mature T-cell malignancies 1.36 (1.03-1.79), diffuse large B-cell lymphoma 1.28 (1.14-1.43), follicular lymphoma 1.28 (1.13-1.44), plasma cell neoplasms 1.12 (1.01-1.24), chronic lymphocytic leukaemia/small lymphocytic lymphoma 1.23 (1.08-1.40), and acute myeloid leukaemia 1.22 (1.04-1.42). There was no significant heterogeneity between subtypes.
conclusionIn middle-aged women, greater body mass index and height were associated with modestly increased risks of many subtypes of haematological malignancy.
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