ArticleEnvironmental science and pollution research international2013
Assessment of DNA damage in Brazilian workers occupationally exposed to pesticides: a study from Central Brazil.
Article in Environmental science and pollution research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Farmers exposed to pesticides have almost five times more DNA damage: a meta-analysis study.Environmental science and pollution research international · 2022Pooled it
- Review of genotoxicity biomonitoring studies of glyphosate-based formulations.Critical reviews in toxicology · 2015Pooled it
- The Toxicity of Mancozeb Used in Viticulture in Southern Brazil: A Cross-Sectional Study.International journal of environmental research and public health · 2025Article
- Article
- Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia.International journal of occupational medicine and environmental health · 2024Article
- Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review.Environmental health perspectives · 2022Article
- Multi-biomarker responses to pesticides in an agricultural population from Central Brazil.The Science of the total environment · 2021Article
- Cultivated areas and rural workers' behavior are responsible for the increase in agricultural intoxications in Brazil? Are these factors associated?Environmental science and pollution research international · 2020Article
- Article
- A longitudinal follow-up study of oxidative stress and DNA damage among farmers exposed to pesticide mixtures.Environmental science and pollution research international · 2019Article
- Micronucleus frequency is correlated with antioxidant enzyme levels in workers occupationally exposed to pesticides.Environmental science and pollution research international · 2018Article
- Evaluating the OGG1 rs1052133 and rs293795 polymorphisms in a sample of rural workers from Central Brazil population: a comparative approach with the 1000 Genomes Project.Environmental science and pollution research international · 2018Article
- Genotoxic effects following exposure to air pollution in street vendors from a high-traffic urban area.Environmental monitoring and assessment · 2018Article
- Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach.Environmental science and pollution research international · 2016Article
- Cytogenetic damage in the oral mucosa cells of bladder cancer patients exposed to tobacco in Southern Tunisia.Environmental science and pollution research international · 2014Article
- Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.Environmental and molecular mutagenesis · 2014Review
- Do GSTT1 and GSTM1 polymorphisms influence intoxication events in individuals occupationally exposed to pesticides?Environmental science and pollution research international · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated 41 rural workers occupationally exposed to pesticides and 32 subjects as a control group, using the micronucleus (MN) and the comet assay. For the comet assay, we evaluated the peripheral blood, and for the MN, we sampled cells from the oral epithelium. Damage to DNA was measured by tail length, % DNA in tail (% tail), olive tail moment (OTM), and tail moment (TM). The exposed group presented an 8× increase in MN frequency, when compared to the control group (p <0.05). When we contrasted the MN frequencies between the individuals that use and do not use personal protective equipment, we found a mean of 7.5 MN (57 % variance) and 12.1 MN (130 % variance), respectively. The binucleated cells were 0.04 and 0.005, in the exposed and control groups, respectively, indicating 8× increase in the number of binucleated cells, when comparing the groups (p <0.05). In the comet assay, we demonstrated statistically significant differences in three parameters (% DNA, OTM, and TM) indicating that the rural workers presented high levels of genomic damages. Our results indicate that occupational exposure to pesticides could cause genome damage in somatic cells, representing a potential health risk to Brazilian rural workers that deal constantly with agrochemicals without adequate personal protection equipment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.