Evidence map›Paper›PMID 23639641›Full record

ReviewGastroenterology clinics of North America2013

Helicobacter pylori in gastric carcinogenesis: mechanisms.

Lydia E Wroblewski, Richard M Peek

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology clinics of North America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Helicobacter pylori Infection and Risk of Gastric Cancer in Korea: A Quantitative Systematic Review.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016
    Pooled it
  2. Epstein-Barr Virus and Gastric Cancer Risk: A Meta-analysis With Meta-regression of Case-control Studies.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
  6. Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Pooled it
  7. Pooled it
  8. Review
  9. Review
  10. World journal of gastroenterology · 2024
    Review
  11. Review
  12. Cross-talk betweenFrontiers in cellular and infection microbiology · 2024
    Article
  13. Review
  14. Review
  15. Review
  16. Spot-light on microbiota in obesity and cancer.International journal of obesity (2005) · 2021
    Review
  17. Biology · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lydia E WroblewskiDepartment of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Richard M Peek

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2009 to 2026
$27.5M
H.Pylori Relationship to Digestive Diseases and CancerR01CA077955 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2003 to 2026
$9.7M
Helicobacter Pylori and Gastrointestinal BiologyR01DK058587 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PEEK, RICHARD M. · 2001 to 2024
$7.8M
H PYLORI RELATIONSHIP TO DIGESTIVE DISEASES AND CANCERR29CA077955 · NCI · VANDERBILT UNIVERSITY · PI PEEK, RICHARD M · 1997 to 2001
$294k
NCI NIH HHS P01 CA116087NCI NIH HHS R01 CA077955NCI NIH HHS R01 CA77955NCI NIH HHS R29 CA077955NIDDK NIH HHS DK-58404NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK058587NIDDK NIH HHS R01 DK58587
6 · The paper itself

Abstract

Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pylori infection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.

Indexed as

CarcinogenesisHelicobacter pyloriAntigens, BacterialBacterial Outer Membrane ProteinsBacterial ProteinsHelicobacter InfectionsHumansStomach NeoplasmsVirulence FactorsAntigens, BacterialBacterial Outer Membrane ProteinsBacterial ProteinscagA protein, Helicobacter pyloriVacA protein, Helicobacter pyloriVirulence Factors

Identifiers

PMID23639641
PMCPMC3648881

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.