ArticleJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2013
Factors associated with survival for patients with glioblastoma with poor pre-operative functional status.
Article in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Association between medical academic genealogy and publication outcome: impact of unconscious bias on scientific objectivity.Acta neurochirurgica · 2019Pooled it
- Predictive value of temporal muscle thickness for prognosis in newly diagnosed IDH wild-type glioblastoma patients: evaluated for a Chinese population.European radiology · 2025Article
- Functional State and Rehabilitation of Patients after Primary Brain Tumor Surgery for Malignant and Nonmalignant Tumors: A Prospective Observational Study.Current oncology (Toronto, Ont.) · 2023Observational
- Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review.Cancers · 2023Review
- Incidental prostate-specific membrane antigen-avid glioblastoma detected onRadiology case reports · 2022Article
- Peritumoral edema status of glioblastoma identifies patients reaching long-term disease control with specific progression patterns after tumor resection and high-dose proton boost.Journal of cancer research and clinical oncology · 2021Article
- Prognostic value of tumour volume in patients with a poor Karnofsky performance status scale - a bicentric retrospective study.BMC neurology · 2021Article
- Prognostic relevance of temporal muscle thickness as a marker of sarcopenia in patients with glioblastoma at diagnosis.European radiology · 2021Article
- Clinical characteristics and risk factors of perioperative outcomes in elderly patients with intracranial tumors.Neurosurgical review · 2021Article
- Prognostic and Predictive Factors in Elderly Patients With Glioblastoma: A Single-Center Retrospective Study.Frontiers in aging neuroscience · 2021Article
- Brachyury-YAP Regulatory Axis Drives Stemness and Growth in Cancer.Cell reports · 2017Article
- Predicting surgical outcome in patients with glioblastoma multiforme using pre-operative magnetic resonance imaging: development and preliminary validation of a grading system.Neurosurgical review · 2017Article
- Treatment and outcomes for glioblastoma in elderly compared with non-elderly patients: a population-based study.Current oncology (Toronto, Ont.) · 2017Article
- Rehabilitation of motor dysfunction in primary brain tumor patientsNeuro-oncology practice · 2015Review
- Clinical implications of motor deficits related to brain tumorsNeuro-oncology practice · 2015Review
- A new functional classification system (FGA/B) with prognostic value for glioma patients.Scientific reports · 2015Article
- Clinical experience of glioma surgery using "tailed bullet": overcoming the limitations of conventional neuro-navigation guided surgery.Yonsei medical journal · 2015Article
- The relative value of postoperative versus preoperative Karnofsky Performance Scale scores as a predictor of survival after surgical resection of glioblastoma multiforme.Journal of neuro-oncology · 2015Article
- Treating glioblastoma patients with poor performance status: where do we go from here?CNS oncology · 2014Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Patients with glioblastoma (GB) are known to have poor prognoses, and among these patients, those with poor neurological function have an even poorer prognosis. Consequently, aggressive surgeries and adjuvant therapies are often withheld because of this dismal outlook. The effects of aggressive therapies in this small subset of patients remain unknown. The goal of this study was to evaluate outcomes and factors associated with survival for poor functioning patients who underwent aggressive resection of their GB. Adult patients who underwent surgical resection of an intracranial primary GB at an academic tertiary-care institution between 1997 and 2007 were retrospectively reviewed. Patients with a Karnofsky Performance Scale (KPS) score of ≤60 were included. A total of 100 patients with primary GB met the inclusion criteria. The average age (± standard deviation) and KPS score of this cohort were 54 ± 15 years and 53 ± 12, respectively. No patient (0%) experienced perioperative mortality, and 0 (0%), 10 (10%), and 3 (3%) of patients incurred a new or increasing language, motor, and visual deficit, respectively. At last follow-up, 88 (88%) patients died with a median survival of 6.6 months. The factors associated with improved survival were age <65 year (p = 0.005), tumor size >2 cm (p = 0.01), radical tumor resection (p=0.01), and temozolomide (p = 0.001). This study identifies a subset of patients with poor functional status who may benefit from aggressive surgical resection.
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