ArticleBiomaterials2013
Engineered cell-laden human protein-based elastomer.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 117 citations in OpenAlex.
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- Biofabrication of engineered blood vessels for biomedical applications.Science and technology of advanced materials · 2024Review
- Soft, strong, tough, and durable bio-hydrogels via maximizing elastic entropy.Advanced functional materials · 2023Article
- Accelerating aging with dynamic biomaterials: Recapitulating aged tissue phenotypes in engineered platforms.iScience · 2023Review
- Protein-Based Biological Materials: Molecular Design and Artificial Production.Chemical reviews · 2023Review
- Soft, strong, tough, and durable protein-based fiber hydrogels.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Photocrosslinkable methacrylated gelatin hydrogel as a cell-friendly injectable delivery system for chlorhexidine in regenerative endodontics.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications.Gels (Basel, Switzerland) · 2022Review
- Systematic optimization of visible light-induced crosslinking conditions of gelatin methacryloyl (GelMA).Scientific reports · 2021Article
- Engineering elastic sealants based on gelatin and elastin-like polypeptides for endovascular anastomosis.Bioengineering & translational medicine · 2021Article
- Adaptable hydrogel with reversible linkages for regenerative medicine: Dynamic mechanical microenvironment for cells.Bioactive materials · 2021Review
- Thixotropic Hydrogels Composed of Self-Assembled Nanofibers of Double-Hydrophobic Elastin-Like Block Polypeptides.International journal of molecular sciences · 2021Article
- BoneMA-synthesis and characterization of a methacrylated bone-derived hydrogel for bioprinting ofBiofabrication · 2021Article
- Human-Recombinant-Elastin-Based Bioinks for 3D Bioprinting of Vascularized Soft Tissues.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Self-Folding 3D Silk Biomaterial Rolls to Facilitate Axon and Bone Regeneration.Advanced healthcare materials · 2020Article
- Advances in Plant-Derived Scaffold Proteins.Frontiers in plant science · 2020Review
- Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Review
- Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair.Tissue engineering. Part A · 2018Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Elastic tissue equivalence is a vital requirement of synthetic materials proposed for many resilient, soft tissue engineering applications. Here we present a bioelastomer made from tropoelastin, the human protein that naturally facilitates elasticity and cell interactions in all elastic tissues. We combined this protein's innate versatility with fast non-toxic fabrication techniques to make highly extensible, cell compatible hydrogels. These hydrogels can be produced in less than a minute through photocrosslinking of methacrylated tropoelastin (MeTro) in an aqueous solution. The fabricated MeTro gels exhibited high extensibility (up to 400%) and superior mechanical properties that outperformed other photocrosslinkable hydrogels. MeTro gels were used to encapsulate cells within a flexible 3D environment and to manufacture highly elastic 2D films for cell attachment, growth, and proliferation. In addition, the physical properties of this fabricated bioelastomer such as elasticity, stiffness, and pore characteristics were tuned through manipulation of the methacrylation degree and protein concentration. This photocrosslinkable, functional tissue mimetic gel benefits from the innate biological properties of a human elastic protein and opens new opportunities in tissue engineering.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.