ArticleBrain, behavior, and immunity2013
Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias.
Article in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of parasitic infection on mental health and illness in humans in Africa: a systematic review.Parasitology · 2022Pooled it
- Sirukumab: A Potential Treatment for Mood Disorders?Advances in therapy · 2017Pooled it
- Endometriosis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Electrocardiography-derived autonomic profiles in depression and suicide risk with insights from the UK Biobank.Npj mental health research · 2025Article
- Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives.Current gene therapy · 2025Review
- What can the psychoneuroimmunology of yoga teach us about depression's psychopathology?Brain, behavior, & immunity - health · 2024Article
- The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes-A Perspective from Psychoneuroimmunology.Biomedicines · 2024Review
- Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis.Frontiers in endocrinology · 2024Review
- Molecular and immunological origins of catatonia.Schizophrenia research · 2024Article
- First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation.Journal of inflammation (London, England) · 2023Article
- Investigating the relationship between early life adversity, inflammation and alcohol use.Addiction biology · 2023Article
- Mind body medicine: a modern bio-psycho-social model forty-five years after Engel.BioPsychoSocial medicine · 2023Article
- Serum NLRP3 Inflammasome and BDNF: Potential Biomarkers Differentiating Reactive and Endogenous Depression.Frontiers in psychiatry · 2022Article
- Goal-striving tendencies moderate the relationship between reward-related brain function and peripheral inflammation.Brain, behavior, and immunity · 2021Article
- SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities?Brain, behavior, & immunity - health · 2020Review
- The BXD21/TyJ recombinant inbred strain as a model for innate inflammatory response in distinct brain regions.Scientific reports · 2020Article
- Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders.International clinical psychopharmacology · 2020Review
- The longitudinal relationship between changes in wellbeing and inflammatory markers: Are associations independent of depression?Brain, behavior, and immunity · 2020Article
- P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes.Cell & bioscience · 2020Review
- Targeting the immune system in the treatment of bipolar disorder.Psychopharmacology · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Evolutionary imperatives bred a vigorous and highly orchestrated behavioral and immune response to the microbial world that served to promote species survival and propagation. The resultant legacy is an inflammatory bias which goes largely unchecked in the modern world and is provoked not only by pathogens but also now by people. In this commentary, the authors' contributions to the special issue on Inflammation and Mental Health are described, beginning with the origins of the inflammatory bias, its roots in genetic predispositions to behavioral adaptations and ultimately maladaptations, and its consequences on the developing brain. In addition, the mechanisms by which the immune system engages behavior are described including a central role for the inflammasome which may serve to link psychological stress with inflammatory and behavioral responses. Neurotransmitter systems that mediate effects of the immune system on behavior are also described along with interactions of the inflammatory bias with depression and their convergent impact on the response to stress and medical illness. Finally, translational implications are discussed including data from a clinical trial using a cytokine antagonist in depressed patients, which suggests an interaction of the inflammatory bias with other evolutionary legacies including those related to food consumption and their modern consequences of obesity and the metabolic syndrome. Taken together, the articles offer a sampling of the rich literature that has evolved regarding the role of the immune system in behavioral disorders. The grounding of this relationship in our evolutionary past may serve to inform future research both theoretically and therapeutically.
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