ArticleDevelopmental cell2013
Arterial and venous progenitors of the major axial vessels originate at distinct locations.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 136 citations in OpenAlex.
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- VEGF/ERK activation and PI3K inhibition together drive a vein-to-artery transition in anbioRxiv : the preprint server for biology · 2025Article
- Hedgehog signaling pathway is an influential factor on vascular biology: a review.Journal of physiology and biochemistry · 2025Review
- Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Zebrafish Kelch-like family member 4 is required for vasculogenesis and hematopoiesis.Developmental biology · 2025Article
- Drivers of vessel progenitor fate define intermediate mesoderm dimensions by inhibiting kidney progenitor specification.Developmental biology · 2025Article
- The role of cardiac lymphatic dysfunction in the progression of myocarditis.Frontiers in cardiovascular medicine · 2025Review
- Venous Malformations: Unraveling Latest Mechanisms and Bridging Gaps in Targeted Therapy Development.International journal of biological sciences · 2025Review
- Direct specification of lymphatic endothelium from mesenchymal progenitors.Nature cardiovascular research · 2025Article
- Lineage labeling with zebrafishbioRxiv : the preprint server for biology · 2024Article
- Pathophysiology in Brain Arteriovenous Malformations: Focus on Endothelial Dysfunctions and Endothelial-to-Mesenchymal Transition.Biomedicines · 2024Review
- The molecular and cellular hematopoietic stem cell specification niche.Experimental hematology · 2024Review
- Endothelial cell transitions in zebrafish vascular development.Development, growth & differentiation · 2024Review
- Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution.Circulation research · 2024Article
- Article
- Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells.APL bioengineering · 2023Article
- Vascular endothelial cell development and diversity.Nature reviews. Cardiology · 2023Review
- Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos.Scientific reports · 2022Article
- Article
- Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Currently, it remains controversial how vascular endothelial progenitor cells (angioblasts) establish their arterial or venous fates. We show using zebrafish that the arterial progenitors of the major axial vessels originate earlier and closer to the midline than the venous progenitors. Both medial and lateral progenitor populations migrate to distinct arterial and venous positions and not into a common precursor vessel as previously suggested. Overexpression of VEGF or Hedgehog (Hh) homologs results in the partially randomized distribution of arterial and venous progenitors within the axial vessels. We further demonstrate that the function of the Etv2 transcription factor is required at earlier stages for arterial development than for venous. Our results argue that the medial angioblasts undergo arterial differentiation because they receive higher concentration of Vegf and Hh morphogens than the lateral angioblasts. We propose a revised model of arterial-venous differentiation that explains how angioblasts choose between an arterial and venous fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.