ArticleExperimental gerontology2013
Fasting or caloric restriction for healthy aging.
Article in Experimental gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Fuel Utilization and Circadian Rhythms in Overweight, Older Adults Following Time Restricted Eating - Phase 2 (FAR Phase 2)
Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.Ageing research reviews · 2018Pooled it
- Trial
- Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial.European journal of applied physiology · 2022Trial
- Trial
- Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism.Rejuvenation research · 2015Trial
- Beneficial effects of multisensory and cognitive stimulation on age-related cognitive decline in long-term-care institutions.Clinical interventions in aging · 2014Trial
- Sex-specific effects of automated feeding on lifespan and reproduction inFrontiers in aging · 2026Article
- Vital Role of Visceral Adipose Tissue in Maintaining Cognitive Functions.International journal of molecular sciences · 2025Review
- What are the effects of time-restricted eating upon metabolic health outcomes in individuals with metabolic syndrome: A scoping review.Physiological reports · 2025Article
- Butyrate- and Beta-Hydroxybutyrate-Mediated Effects of Interventions with Pro- and Prebiotics, Fasting, and Caloric Restrictions on Depression: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2024Review
- Joint Effects of Exercise and Ramadan Fasting on Telomere Length: Implications for Cellular Aging.Biomedicines · 2024Article
- Does dietary nitrate boost the effects of caloric restriction on brain health? Potential physiological mechanisms and implications for future research.Nutrition & metabolism · 2023Review
- Short-Term Caloric Restriction and Subsequent Re-Feeding Compromise Liver Health and Associated Lipid Mediator Signaling in Aged Mice.Nutrients · 2023Article
- The Potential of Fasting-Mimicking Diet as a Preventive and Curative Strategy for Alzheimer's Disease.Biomolecules · 2023Review
- CNS Ageing in Health and Neurodegenerative Disorders.Journal of clinical medicine · 2023Review
- Article
- Beneficial effects of intermittent fasting: a narrative review.Journal of Yeungnam medical science · 2023Article
- Alternate-day modified fasting diet improves weight loss, subjective sleep quality and daytime dysfunction in women with obesity or overweight: a randomized, controlled trial.Frontiers in nutrition · 2023Article
- Article
- Intermittent Fasting Alleviates Risk Markers in a Murine Model of Ulcerative Colitis by Modulating the Gut Microbiome and Metabolome.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss of independence, and increased risk of mortality. To date, prolonged caloric restriction (i.e., a reduction in caloric intake without malnutrition) is the only non-genetic intervention that has consistently been found to extend both mean and maximal life span across a variety of species. Most individuals have difficulty sustaining prolonged caloric restriction, which has led to a search for alternative approaches that can produce similar to benefits as caloric restriction. A growing body of evidence indicates that fasting periods and intermittent fasting regimens in particular can trigger similar biological pathways as caloric restriction. For this reason, there is increasing scientific interest in further exploring the biological and metabolic effects of intermittent fasting periods, as well as whether long-term compliance may be improved by this type of dietary approach. This special will highlight the latest scientific findings related to the effects of both caloric restriction and intermittent fasting across various species including yeast, fruit flies, worms, rodents, primates, and humans. A specific emphasis is placed on translational research with findings from basic bench to bedside reviewed and practical clinical implications discussed.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.