Evidence map›Paper›PMID 23639309›Full record

ReviewCurrent opinion in cell biology2013

Rab GTPase regulation of membrane identity.

Suzanne R Pfeffer

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed.

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157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Suzanne R PfefferDepartment of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu

Funding

INTRACELLULAR TRANSPORT--THE MANNOSE/PHOSPHATE RECEPTORR01DK037332 · NIDDK · STANFORD UNIVERSITY · PI PFEFFER, SUZANNE R · 1986 to 2019
$4.7M
NIDDK NIH HHS R01 DK037332
6 · The paper itself

Abstract

A fundamental question in cell biology is how cells determine membrane compartment identity and the directionality with which cargoes pass through the secretory and endocytic pathways. The discovery of so-called 'Rab cascades' provides a satisfying molecular mechanism that helps to resolve this paradox. One Rab GTPase has the ability to template the localization of the subsequent acting Rab GTPase along a given transport pathway. Thus, in addition to determining compartment identity and functionality, Rab GTPases are likely able to order the events of membrane trafficking. This review will highlight recent advances in our understanding of Rabs and Rab cascades.

Indexed as

Protein TransportCell MembraneEndocytosisHumansIntracellular Membranesrab GTP-Binding ProteinsSecretory PathwayYeastsrab GTP-Binding Proteins

Identifiers

PMID23639309
PMCPMC3729790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.