Evidence map›Paper›PMID 23639206›Full record

ArticleNeurobiology of aging2013

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.

Joanna Collerton, Deepthi Ashok, Carmen Martin-Ruiz, Angela Pyle, Gavin Hudson, Mohammad Yadegarfar, Karen Davies, Carol Jagger, Thomas von Zglinicki, Thomas B L Kirkwood and 1 more

Abstract read
In one paragraph

Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joanna CollertonInstitute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
Deepthi Ashok
Carmen Martin-Ruiz
Angela Pyle
Gavin Hudson
Mohammad Yadegarfar
Karen Davies
Carol Jagger
Thomas von Zglinicki
Thomas B L Kirkwood
Patrick F Chinnery

Funding

Biotechnology and Biological Sciences Research Council G0500997Biotechnology and Biological Sciences Research Council G0601333Medical Research Council G0500997Medical Research Council G0601333Medical Research Council MR/J50001X/1Medical Research Council MR/K000608/1Parkinson's UK F-1202Wellcome Trust 096919Wellcome Trust 101876
6 · The paper itself

Abstract

Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an "unhealthy aging" phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging.

Indexed as

Aged, 80 and overAgingCohort StudiesDNA, MitochondrialFrail ElderlyGenetic VariationHaplotypesHumansLongevityDNA, MitochondrialAgingFrailtyGeneticsMitochondrial DNA

Identifiers

PMID23639206
PMCPMC3906612

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.