ArticleJournal of neurodevelopmental disorders2013
Autism and the broad autism phenotype: familial patterns and intergenerational transmission.
Article in Journal of neurodevelopmental disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Heritability of autism spectrum disorders: a meta-analysis of twin studies.Journal of child psychology and psychiatry, and allied disciplines · 2016Pooled it
- One size does not fit all for parent-mediated autism interventions: A randomized clinical trial.Autism : the international journal of research and practice · 2023Trial
- SAFE, a new therapeutic intervention for families of children with autism: a randomised controlled feasibility trial.BMJ open · 2020Trial
- Access to Autism Behavioral Therapy Services: An Analysis of 2022-2023 National Survey of Children's Health Data.Journal of autism and developmental disorders · 2026Article
- Subclinical neuropsychiatric trait variation in parents of children with autism spectrum disorder: a cohort study.Molecular autism · 2026Article
- Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.Translational psychiatry · 2026Article
- Broad autism phenotype and parental personality in parents of preschoolers with autism: associations with social and behavioral profile.Frontiers in child and adolescent psychiatry · 2026Article
- Filled Pause Use in Autistic Adults and Their First-Degree Relatives: Gender Differences and Within-Family Associations.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Sex Differences in the Broad Autism Phenotype: Insights from the Australian Biobank.Journal of autism and developmental disorders · 2025Article
- Deep Phenotyping of the Broader Autism Phenotype in Epilepsy: A Transdiagnostic Marker of Epilepsy and Autism Spectrum Disorder.Annals of the Child Neurology Society · 2025Article
- Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents.Autism research : official journal of the International Society for Autism Research · 2025Article
- How the ASCENT model can help optimize exposure therapies for Autistic clients.Frontiers in psychiatry · 2025Article
- Context effects: discourse structure influences narrative ability in autism and first-degree relatives.Frontiers in psychiatry · 2025Article
- Exploring autistic traits in parents of autistic children: a pilot study on the broader autism phenotype.Frontiers in psychiatry · 2025Article
- Evaluative contexts facilitate implicit mentalizing: relation to the broader autism phenotype and mental health.Scientific reports · 2024Article
- Relationship of autistic traits and the severity of fear of the COVID-19 pandemic in the general population.Frontiers in psychiatry · 2024Article
- Is the association between mothers' autistic traits and childhood autistic traits moderated by maternal pre-pregnancy body mass index?Molecular autism · 2023Article
- Brief Report: Gender-Based Stereotypical Roles of Parents Caring for Autistic Children in Nigeria and South Africa.Journal of autism and developmental disorders · 2023Article
- Similar overall expression, but different profiles, of autistic traits, sensory processing, and mental health between young adult males and females.Research in autism spectrum disorders · 2023Article
- Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism.Journal of autism and developmental disorders · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFeatures of the Broad Autism Phenotype (BAP) are disproportionately prevalent in parents of a child with autism, highlighting familial patterns indicative of heritability. It is unclear, however, whether the presence of BAP features in both parents confers an increased liability for autism. The current study explores whether the presence of BAP features in two biological parents occurs more frequently in parents of a child with autism relative to comparison parents, whether parental pairs of a child with autism more commonly consist of one or two parents with BAP features, and whether these features are associated with severity of autism behaviors in probands.
methodSeven hundred eleven parents of a child with an autism spectrum disorder and 981 comparison parents completed the Broad Autism Phenotype Questionnaire. Parents of a child with autism also completed the Social Communication Questionnaire.
resultsAlthough parental pairs of a child with autism were more likely than comparison parental pairs to have both parents characterized by the presence of the BAP, they more commonly consisted of a single parent with BAP features. The presence of the BAP in parents was associated with the severity of autism behaviors in probands, with the lowest severity occurring for children of parental pairs in which neither parent exhibited a BAP feature. Severity did not differ between children of two affected parents and those of just one.
conclusionsCollectively, these findings indicate that parental pairs of children with autism frequently consist of a single parent with BAP characteristics and suggest that future studies searching for implicated genes may benefit from a more narrow focus that identifies the transmitting parent. The evidence of intergenerational transmission reported here also provides further confirmation of the high heritability of autism that is unaccounted for by the contribution of de novo mutations currently emphasized in the field of autism genetics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.