ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2014
Cleft Palate in a Mouse Model of SOX2 Haploinsufficiency.
Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Polymorphisms inJournal of Taibah University Medical Sciences · 2025Article
- Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness.Nature genetics · 2023Article
- Chromatin conformation of human oral epithelium can identify orofacial cleft missing functional variants.International journal of oral science · 2022Article
- Sorting Sox: Diverse Roles for Sox Transcription Factors During Neural Crest and Craniofacial Development.Frontiers in physiology · 2020Review
- Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial Development.Journal of dental research · 2018Article
- The "domestication syndrome" in mammals: a unified explanation based on neural crest cell behavior and genetics.Genetics · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWhile SEX-determining region Y-Box 2 (SOX2) mutations are typically recognized as yielding ocular and central nervous system abnormalities, they have also been associated with other craniofacial defects. To elucidate the genesis of the latter, Sox2 hypomorphic (Sox2(HYP)) mice were examined, with particular attention to secondary palatal development.
resultsClefts of the secondary palate were found to be highly penetrant in Sox2(HYP) mice. The palatal clefting occurred in the absence of mandibular hypoplasia and resulted from delayed or failed shelf elevation.
conclusionsSox2 hypomorphism can result in clefting of the secondary palate, an effect that appears to be independent of mandibular hypoplasia and is thus expected to result from an abnormality that is inherent to the palatal shelves and/or their progenitor tissues. Further clinical attention relative to SOX2 mutations as a basis for secondary palatal clefts appears warranted.
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Registered trials
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