ArticleAnnals of clinical microbiology and antimicrobials2013
Genetic characterization of antimicrobial resistance of Shigella flexneri 1c isolates from patients in Egypt and Pakistan.
Article in Annals of clinical microbiology and antimicrobials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Molecular epidemiology of extended-spectrum beta-lactamases and carbapenemases-producing Shigella in Africa: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Antimicrobial resistance in Africa: a systematic review.BMC infectious diseases · 2017Pooled it
- Microbiota Composition Shaped by Seasonal Variation and Environmental Compartments Affects the Abundance of Antimicrobial-Resistant Bacteria in Indonesian Aquaculture.Environmental microbiology reports · 2026Article
- Characterization of multi-resistant Shigella species isolated from raw cow milk and milk products.The Journal of veterinary medical science · 2022Article
- Clonal serotype 1c multidrug-resistantFrontiers in medicine · 2022Article
- Newly Emerged Serotype 1c ofGenes · 2020Article
- Plasmids of Shigella flexneri serotype 1c strain Y394 provide advantages to bacteria in the host.BMC microbiology · 2019Article
- Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.PloS one · 2018Article
- Bacteriophages are the major drivers of Shigella flexneri serotype 1c genome plasticity: a complete genome analysis.BMC genomics · 2017Article
- Genome Sequencing Analysis of AtypicalOsong public health and research perspectives · 2017Article
- Examine the characterization of biofilm formation and inhibition by targeting SrtA mechanism in Bacillus subtilis: a combined experimental and theoretical study.Journal of molecular modeling · 2014Article
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6 authors.
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Abstract
backgroundShigella flexneri serotype 1c emerged as a critical isolate from children in Egypt and Pakistan. The pattern of antimicrobial susceptibility (AMS) and resistance genes of this serotype have yet to be characterized.
findingsSixty nine S. flexneri 1c isolates isolates were identified from both Egypt (n-46) and Pakistan (n = 23) and tested for AMS by disk diffusion method and minimal inhibitory concentrations were also determined. Isolates were genotyped by pulsed field gel electrophoresis (PFGE) and five relevant resistance genes (bla(TEM), bla(SHV), bla(OXA), sulI and sulII) were detected by polymerase chain reaction (PCR) and confirmed by DNA sequencing. High resistance was observed in all isolates for ampicillin (AM >96%); trimethoprim-sulphamethoxazole and tetracycline (>88%). Most AM-resistant isolates from Egypt (70%) harbored bla(TEM) resistance, while 52% of isolates from Pakistan expressed bla(OXA). All isolates were closely related by PFGE, irrespective of source or time of collection. The sulII gene was present in 100% of isolates from pediatric cases in Egypt, 65% of Pakistan isolates, and 53% of isolates from older Egyptian patients.
conclusionsWhile different Shigella serotypes gathered in specific genotypic groups, 1c serotype isolates formed multiple clusters. Although AMS was considerably high to most commonly used drugs, genetic determinants were variable between countries over time. The data stress the need for a more careful selection of antibiotics in the treatment of shigellosis.
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