ArticleInternational journal of ophthalmology2013
Effects of intensive control of blood glucose and blood pressure on microvascular complications in patients with type II diabetes mellitus.
Article in International journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 15 citations in OpenAlex.
- Analysis of serum and urinal copper and zinc in Chinese northeast population with the prediabetes or diabetes with and without complications.Oxidative medicine and cellular longevity · 2013Trial
- Review
- Health Management of Type 2 Diabetes Mellitus and Its Complications: A Machine Learning Algorithm-Based Retrospective Study in Chinese Communities.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- A new perspective on protecting the blood-retinal barrier against injury in diabetic retinopathy: mitophagy.Frontiers in endocrinology · 2025Review
- Determinants of cardiovascular disease among type 2 diabetic patients attending diabetic follow-up clinic in Arba Minch general hospital, southern Ethiopia: an unmatched case-control study.Annals of medicine and surgery (2012) · 2024Article
- Article
- Diabetic Retinopathy-Update on Prevention Techniques, Present Therapies, and New Leads.US ophthalmic review · 2014Article
- Diabetic Retinopathy: An Overview of Treatments.Indian journal of endocrinology and metabolismReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effects of intensive control of blood glucose and blood pressure on microvascular complications in patients with type II diabetes by comparing the therapeutic effects of intensive and standard treatment in patients with type II diabetes.
methodsA total of 107 patients with type II diabetes were randomly assigned into intensive and standard treatment groups. Patients in the intensive treatment group received preterax (perindopril/ indapamide) to control blood pressure, and gliclazide (diamicron) MR to control blood glucose. Patients in the standard treatment group received routine medications or placebo. Urinary microalbumin (UMA), urinary creatinine (UCR), the UMA/UCR ratio, and visual acuity were monitored according to the study design of the ADVANCE trial. Direct ophthalmoscopy and seven-field stereoscopic retinal photography were used to examine the fundi at baseline, and repeated after 5 years of treatment.
resultsThe characteristics of patients in both groups were well balanced at baseline. After 5 years of treatment, visual acuity was found to be decreased in the standard group (P=0.04), but remained stable in the intensive group. The severity of diabetic retinopathy had not progressed in patients in the intensive group, but had deteriorated in the standard group (P=0.0006). The UMA/UCR ratio was not obviously changed in patients in the intensive group, whereas it was significantly increased in the standard group (P=0.00).
conclusionIntensive control of blood glucose and blood pressure can decrease the incidence or slow the progression of microvascular complications in patients with type II diabetes, and maintain stable vision.
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